Ozeki T, Imanishi K, Uchiyama T, Sanefuji H, Fujiwara H, Mizuno S, Tanaka N, Suzuki I
Third Department of Internal Medicine, School of Medicine, University of Occupational and Environmental Health, Kitakyshu, Japan.
Br J Exp Pathol. 1988 Aug;69(4):589-95.
The relationship between alpha 1-acid glycoprotein (alpha 1-AG) and liver fibrosis was studied. Immunoperoxidase staining of liver specimens from patients with chronic hepatitis showed large amounts of alpha 1-AG to be located primarily in hepatocytes adjacent to areas of piecemeal necrosis, bridging fibrosis and fibrous septa. In patients with severe chronic active hepatitis, hepatocytes throughout the liver stained similarly to those adjacent to areas of piecemeal necrosis. In cell cultures of human embryonal lung (HEL) fibroblasts, addition to the culture medium of alpha 1-AG promoted cell growth. It is known that alpha 1-AG is also produced in the liver. It thus appears likely that alpha 1-AG is a promoter of hepatic fibrosis in chronic hepatitis.
研究了α1-酸性糖蛋白（α1-AG）与肝纤维化之间的关系。对慢性肝炎患者肝脏标本进行免疫过氧化物酶染色显示，大量α1-AG主要位于靠近碎片状坏死、桥接纤维化和纤维间隔区域的肝细胞中。在重度慢性活动性肝炎患者中，整个肝脏的肝细胞染色情况与靠近碎片状坏死区域的肝细胞相似。在人胚肺（HEL）成纤维细胞的细胞培养中，向培养基中添加α1-AG可促进细胞生长。已知α1-AG也在肝脏中产生。因此，α1-AG似乎很可能是慢性肝炎中肝纤维化的促进因子。
