Texas Tech University Health Sciences Center School of Medicine, USA.
Texas Tech University Health Sciences Center Clinical Research Institute, USA.
Burns. 2019 Jun;45(4):841-848. doi: 10.1016/j.burns.2018.11.001. Epub 2018 Dec 7.
The purpose of this study is to use a retrospective cohort of burn patients to evaluate the contribution of oxandrolone on burn care outcomes. Longitudinal clinical data is used to analyze outcomes from a new perspective. Our random-effects longitudinal regression analysis model used temporal clinical data to evaluate oxandrolone's impact on outcomes (oxandrolone/non-oxandrolone n=50/11, median length of stay [LOS]=42.2/39.3, mean weight (kg)=192.2/207.6, mean initial prealbumin (mg/dL) 10.1/7.5). The resultant predictive models (p<0.001) described how certain factors influence clinically significant outcomes via a robust data analysis method. LOS was predicted and extended by a greater magnitude of 3rd-degree versus 2nd-degree burns (1.01 versus 0.85 additional days for each %TBSA, p<0.001). Weight was decreased by LOS (145.2g lost per day, p<0.001). Oxandrolone improved prealbumin (3.503mg/dL increase, p<0.001) but instead did not influence patient weight (p>0.05) nor LOS (5.27days shortening, p=0.361). Prealbumin over time was also influenced by initial value (0.293mg/dL, p=0.003), LOS (0.072mg/dL increase per additional day, p<0.001), and the presence of inhalation injury (2.652mg/dL decrease if present, p=0.009). Oxandrolone appears to benefit anabolic protein production. It is difficult to isolate the role of oxandrolone on major outcomes due to the concomitant influence of other variables.
本研究旨在通过回顾性烧伤患者队列评估氧雄龙对烧伤治疗结果的影响。使用纵向临床数据从新的角度分析结果。我们的随机效应纵向回归分析模型使用时间临床数据评估氧雄龙对结果的影响（氧雄龙/非氧雄龙 n=50/11，中位数住院时间[LOS]=42.2/39.3，平均体重（kg）=192.2/207.6，平均初始前白蛋白（mg/dL）10.1/7.5）。结果预测模型（p<0.001）通过稳健的数据分析方法描述了某些因素如何通过影响临床显著结果。三度烧伤比二度烧伤导致 LOS 更长（每 1%TBSA 增加 1.01 天，0.85 天，p<0.001）。体重随着 LOS 而减轻（每天损失 145.2g，p<0.001）。氧雄龙改善了前白蛋白（增加 3.503mg/dL，p<0.001），但对患者体重（p>0.05）和 LOS（缩短 5.27 天，p=0.361）没有影响。前白蛋白随着时间的推移也受到初始值（0.293mg/dL，p=0.003）、LOS（每天增加 0.072mg/dL，p<0.001）和吸入性损伤的存在（如果存在则减少 2.652mg/dL，p=0.009）的影响。氧雄龙似乎有益于合成代谢蛋白的产生。由于其他变量的共同影响，很难孤立氧雄龙对主要结果的作用。
