Lehtinen T
Department of Oncology, Tampere University Central Hospital, Finland.
Cancer Detect Prev. 1988;12(1-6):125-31.
We have studied the serum beta 2-microglobulin (beta 2m) and thymidine kinase (TK) levels in 19 newly diagnosed lymphoma patients. The proportion of the S-phase cells (SPF) was determined by flow cytometry from subsequently taken tumor biopsy material. A positive correlation between SPF and TK (r = 0.4, P = 0.1), but not between SPF and beta 2m, was seen in the whole material. Sixty-three percent of the high-grade malignancy non-Hodgkin lymphomas (5/8) showed high proliferative activity in both the SPF and TK analyses. Furthermore, high tumor SPF and enhanced serum TK levels reflected equally well and consistently the clinical outcome of the underlying disease.
我们研究了19例新诊断淋巴瘤患者的血清β2-微球蛋白（β2m）和胸苷激酶（TK）水平。通过流式细胞术从随后获取的肿瘤活检材料中测定S期细胞比例（SPF）。在整个研究材料中，观察到SPF与TK之间呈正相关（r = 0.4，P = 0.1），但SPF与β2m之间无相关性。63%的高级别恶性非霍奇金淋巴瘤（5/8）在SPF和TK分析中均显示出高增殖活性。此外，高肿瘤SPF和血清TK水平升高同样良好且一致地反映了基础疾病的临床结局。
