Steinhauer H B
Department of Internal Medicine, University of Freiburg, FRG.
Clin Nephrol. 1988;30 Suppl 1:S29-33.
Various endogenous compounds and drugs influence different determinants of peritoneal transport. Catecholamines affect vascular diameter and mesenteric blood flow. Several gastrointestinal hormones were found to induce splanchnic vasodilation and to augment the effective vascular surface. Different prostanoids, histamine, and bradykinin influence peritoneal mass transfer by increasing vascular permeability. Vasodilative acting drugs, diuretics and surface active compounds were found to augment peritoneal solute clearances and water efflux by acting on peritoneal vessels or the serosal surface of the peritoneal membrane. Hyperosmolar dialysis solutions increase ultrafiltration and contribute to total peritoneal clearance by convective transport. The present paper aims to summarize the current knowledge on pharmacological and physiological manipulation of peritoneal transport function and to show some ways of its clinical use.
多种内源性化合物和药物会影响腹膜转运的不同决定因素。儿茶酚胺会影响血管直径和肠系膜血流量。已发现几种胃肠激素可诱导内脏血管舒张并增加有效血管表面积。不同的前列腺素、组胺和缓激肽通过增加血管通透性来影响腹膜物质转运。已发现具有血管舒张作用的药物、利尿剂和表面活性化合物可通过作用于腹膜血管或腹膜的浆膜表面来增加腹膜溶质清除率和水流出量。高渗透析液可增加超滤，并通过对流运输促进总的腹膜清除率。本文旨在总结目前关于腹膜转运功能的药理学和生理学调控的知识，并展示其临床应用的一些方式。
