Yang Kun, Chen Jiu, Xiang Jing, Liu Hongyi, Zou Yuanjie, Kan Wenwu, Liu Yong, Li Lixin
Department of Neurosurgery, the Affiliated Brain Hospital of Nanjing Medical University, Nanjing, China.
Institute of Neuropsychiatry, the Affiliated Brain Hospital of Nanjing Medical University, Fourth Clinical College of Nanjing Medical University, Nanjing, China.
World Neurosurg. 2019 Mar;123:e609-e620. doi: 10.1016/j.wneu.2018.11.235. Epub 2018 Dec 8.
To quantify the low- to high-frequency range of abnormal brain activities and assess the histopathologic and clinical correlation in patients with glioma.
Twenty-five patients with glioma and 20 healthy controls were examined with a magnetoencephalography (MEG) system. MEG data collected in 6 frequency bands, including 1-4 Hz, 4-8 Hz, 8-12 Hz, 12-30 Hz, 30-45 Hz, and 55-75 Hz, were analyzed by neuropathology to assess neuromagnetic signatures of glioma grade.
Compared with controls, patients with glioma showed greatly altered brain activities in 4-8 Hz, 8-12 Hz, and 55-75 Hz. Magnetic source power of brain activities in 4-8 Hz and 55-75 Hz in patients with high-grade gliomas significantly differed from that in patients with low-grade gliomas. The magnitude of source power of brain activities in 4-8 Hz and 55-75 Hz had marked correlation with the grading of gliomas in histopathological analyses.
The degree of neuromagnetic source abnormality is a potential biomarker for noninvasive assessment of glioma grade. Because MEG tests can be performed noninvasively and preoperatively, MEG may play an important role in clinical biopsies and surgical planning for patients with brain gliomas in the future.
量化脑胶质瘤患者异常脑活动的低频至高频率范围，并评估其组织病理学与临床的相关性。
采用脑磁图（MEG）系统对25例脑胶质瘤患者和20名健康对照者进行检查。收集MEG在6个频段（包括1 - 4Hz、4 - 8Hz、8 - 12Hz、12 - 30Hz、30 - 45Hz和55 - 75Hz）的数据，并通过神经病理学分析来评估脑胶质瘤分级的神经磁特征。
与对照组相比，脑胶质瘤患者在4 - 8Hz、8 - 12Hz和55 - 75Hz频段的脑活动有显著改变。高级别脑胶质瘤患者在4 - 8Hz和55 - 75Hz频段的脑活动磁源功率与低级别脑胶质瘤患者有显著差异。在组织病理学分析中，4 - 8Hz和55 - 75Hz频段的脑活动源功率大小与脑胶质瘤分级有显著相关性。
神经磁源异常程度是脑胶质瘤分级无创评估的潜在生物标志物。由于MEG检测可在术前无创进行，未来MEG可能在脑胶质瘤患者的临床活检和手术规划中发挥重要作用。
