Department of Colorectal Surgery, First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, 310003, China; Key Laboratory of Precision Diagnosis and Treatment for Hepatobiliary and Pancreatic Tumor of Zhejiang Province, First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.
Department of Colorectal Surgery, First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, 310003, China.
Biomed Pharmacother. 2019 Feb;110:473-481. doi: 10.1016/j.biopha.2018.11.082. Epub 2018 Dec 6.
Aberrant Wnt/β-catenin signaling has often been reported in different cancers, particularly colorectal cancer (CRC), and this signaling cascade is central to carcinogenesis. Approximately 80% of CRC cases harbor mutations in the adenomatous polyposis coli gene, and half of the remaining cases feature mutations in the β-catenin gene that affect the Wnt/β-catenin signaling pathway. Unsurprisingly, the Wnt/β-catenin signaling pathway has potential value as a therapeutic target in the treatment of CRC. Several inhibitors of the Wnt/β-catenin signaling pathway have been developed for CRC treatment, but so far no molecular therapeutic targeting this pathway has been incorporated into oncological practice. In this review, we discuss the role of Wnt/β-catenin signaling in CRC and its potential as a target of innovative therapeutic approaches for CRC.
异常的 Wnt/β-catenin 信号通路在不同的癌症中经常被报道，特别是结直肠癌（CRC），并且该信号级联反应是致癌作用的核心。大约 80%的 CRC 病例携带有腺瘤性结肠息肉基因的突变，而其余病例中有一半存在影响 Wnt/β-catenin 信号通路的β-catenin 基因突变。毫不奇怪，Wnt/β-catenin 信号通路作为 CRC 治疗的治疗靶点具有潜在价值。已经开发了几种用于 CRC 治疗的 Wnt/β-catenin 信号通路抑制剂，但到目前为止，还没有针对该通路的分子治疗方法被纳入肿瘤学实践。在这篇综述中，我们讨论了 Wnt/β-catenin 信号通路在 CRC 中的作用及其作为 CRC 创新治疗方法的潜在靶点。
