系统性炎症在未感染 HIV 的年轻男男性行为者和 HIV 感染者中均升高。
Systemic inflammation is elevated among both HIV-uninfected and HIV-infected young MSM.
机构信息
Northwestern University, Chicago, IL, USA.
出版信息
AIDS. 2019 Mar 15;33(4):757-759. doi: 10.1097/QAD.0000000000002093.
Abstract
: Evidence suggests that systemic inflammation increases due to HIV infection. C-reactive protein (CRP), interleukin (IL)-6 and tumour necrosis factor (TNF)-α values were compared between HIV-positive and HIV-negative young MSM and transgender women. CRP values were more than 3 mg/l among 49.8% of participants. HIV status was not significantly associated with CRP nor IL-6. TNF-α was significantly higher among HIV-positive participants. These results suggest the need for further study of the causes and health consequences of elevated systemic inflammation among this population.
摘要
有证据表明，由于 HIV 感染，系统性炎症会增加。我们比较了 HIV 阳性和 HIV 阴性的年轻男男性行为者和跨性别女性之间的 C 反应蛋白（CRP）、白细胞介素（IL）-6 和肿瘤坏死因子（TNF）-α 值。49.8%的参与者的 CRP 值超过 3mg/L。HIV 状况与 CRP 和 IL-6 均无显著相关性。HIV 阳性参与者的 TNF-α 显著更高。这些结果表明，需要进一步研究该人群中系统性炎症升高的原因和健康后果。
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