Suggett A J, Barer G R
Department of Medicine, Sheffield University, Royal Hallamshire Hospital, U.K.
Eur Heart J. 1988 Sep;9 Suppl J:13-8. doi: 10.1093/eurheartj/9.suppl_j.13.
The rat model of chronic hypoxic pulmonary hypertension has been extensively studied and shows many of the features seen in man with chronic pulmonary hypertension. The development and reversibility of these changes by various treatments and by drugs is discussed. The experimental model may provide valuable clues as to the mechanisms involved in the aetiology of pulmonary hypertension in man.
慢性低氧性肺动脉高压大鼠模型已得到广泛研究，呈现出许多人类慢性肺动脉高压所具有的特征。本文讨论了通过各种治疗方法和药物对这些变化的发展及可逆性的影响。该实验模型可能为人类肺动脉高压病因学中涉及的机制提供有价值的线索。
