Renjen Pushpendra Nath, Chaudhari Dinesh Mohan, Shilpi U S, Zutshi Dhruv, Ahmad Kamal
Department of Neurosciences, Institute of Neurosciences, Indraprastha Apollo Hospitals, New Delhi, India.
Department of Neurosciences, Institute of Neurosciences/Internal Medicine, Indraprastha Apollo Hospitals, New Delhi, India.
Ann Indian Acad Neurol. 2018 Oct-Dec;21(4):311-314. doi: 10.4103/aian.AIAN_411_17.
Paraneoplastic syndromes are a rare heterogeneous group of disorders that are indicators of the underlying occult malignancy. Subacute cerebellar ataxia in a patient with a known cancer is often due to metastatic invasion or other complications of the cancer, such as infection, coagulopathy, metabolic and nutritional deficits, or side effects of treatment. When tumor- and treatment-related causes have been excluded, the patient is considered to suffer from paraneoplastic cerebellar degeneration (PCD). We report a case of PCD that presented before any evidence of tumor, but early diagnostic workup and clinical vigilance helped us to find the underlying high-grade ovarian adenocarcinoma which was surgically removed later.
副肿瘤综合征是一组罕见的异质性疾病，是潜在隐匿性恶性肿瘤的指标。已知患有癌症的患者出现亚急性小脑共济失调，通常是由于癌症的转移侵袭或其他并发症，如感染、凝血病、代谢和营养缺乏或治疗副作用。当排除肿瘤和治疗相关原因后，该患者被认为患有副肿瘤性小脑变性（PCD）。我们报告一例PCD病例，该病例在出现任何肿瘤证据之前就已出现，但早期诊断检查和临床警惕性帮助我们发现了潜在的高级别卵巢腺癌，该腺癌后来通过手术切除。
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