副肿瘤性神经系统综合征
Paraneoplastic neurological syndromes.
作者信息
Leypoldt F, Wandinger K-P
机构信息
Department of Neurology, University Medical-Center Hamburg-Eppendorf, Hamburg; Josep Dalmau's Laboratory, Catalan Institution for Research and Advanced Studies (ICREA), August Pi i Sunyer Biomedical Research Institute (IDIBAPS), Barcelona, Spain.
出版信息
Clin Exp Immunol. 2014 Mar;175(3):336-48. doi: 10.1111/cei.12185.
Abstract
Paraneoplastic neurological syndromes are immune-mediated erroneous attacks on the central or peripheral nervous systems, or both, directed originally against the tumour itself. They have been known for more than 40 years, but recently the discovery of new subgroups of paraneoplastic encephalitis syndromes with a remarkably good response to immune therapy has ignited new clinical and scientific interest. Knowledge of these subgroups and their associated autoantibodies is important in therapeutic decision-making. However, the abundance of new autoantibodies and syndromes can be confusing. This review paper summarizes current knowledge and new developments in the field of paraneoplastic neurological syndromes, their classification, pathophysiology and treatment.
摘要
副肿瘤性神经系统综合征是针对中枢或周围神经系统，或两者的免疫介导的错误攻击，最初是针对肿瘤本身的。它们已被发现40多年，但最近发现的对免疫治疗有显著良好反应的副肿瘤性脑炎综合征新亚组引发了新的临床和科学兴趣。了解这些亚组及其相关自身抗体对治疗决策很重要。然而，新出现的大量自身抗体和综合征可能会令人困惑。这篇综述文章总结了副肿瘤性神经系统综合征领域的当前知识和新进展，包括它们的分类、病理生理学和治疗方法。
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