在白血病异基因骨髓移植中，T细胞去除与甲氨蝶呤作为移植物抗宿主病预防措施的比较
T-cell depletion versus methotrexate as GvHD-prophylaxis in allogeneic bone marrow transplantation for leukaemia.
作者信息
Wiesneth M, Hertenstein B, Bunjes D, Schmeiser T, Arnold R, Heimpel H, Heit W
机构信息
Internal Medicine III, University of Ulm, F.R.G.
出版信息
Eur J Haematol. 1988 Sep;41(3):243-9. doi: 10.1111/j.1600-0609.1988.tb01188.x.
Graft-versus-host disease (GvHD) prophylaxis using methotrexate (23 patients) and T-cell depletion of the graft (40 patients) was compared in 63 allogeneic bone marrow transplantations (BMT) for leukaemia. T-cell depletion significantly reduced (p = 0.001) the incidence of GvHD from 68% to 11% and the GvHD-associated mortality from 79% to 5%. Actuarial disease-free survival for low-risk patients (57% with T-cell depletion and 47% with MTX) was not significantly improved, due to graft failure and possibly due to a higher leukaemic relapse rate after T-cell depletion. Prevention of graft failure after T cell-depleted BMT is essential and could also reduce the risk of leukaemic relapse by improved engraftment.
在63例白血病异基因骨髓移植（BMT）中，对比了使用甲氨蝶呤预防移植物抗宿主病（GvHD）（23例患者）和对移植物进行T细胞去除（40例患者）的效果。T细胞去除显著降低了（p = 0.001）GvHD的发生率，从68%降至11%，并将GvHD相关死亡率从79%降至5%。低风险患者的无病生存率（T细胞去除组为57%，甲氨蝶呤组为47%）未得到显著改善，这是由于移植物失败，也可能是因为T细胞去除后白血病复发率较高。在T细胞去除的BMT后预防移植物失败至关重要，并且通过改善植入还可以降低白血病复发的风险。
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