Ayyash Hani, Sirdah Mahmoud
Department of Hematology, European Gaza Hospital, Khanyounis, Gaza Strip, Palestine.
Department of Biology, Faculty of Science, Al Azhar University-Gaza, P O Box 1277, Gaza, Palestine.
Int J Health Sci (Qassim). 2018 Nov-Dec;12(6):18-24.
In Gaza Strip, Palestine, β-thalassemia is a major public health problem where more than 300 β-thalassemia major (βTM) patients are currently being managed at governmental hospitals. We set up to evaluate the hematological and biochemical aspects of our βTM patients at the Gaza European hospital and their correlation with iron overload.
Our study included 65 transfusion-dependent βTM, as well as 37 apparently healthy subjects as control group. The hematological and biochemical evaluations included complete blood count, coagulation profile liver and kidney function tests, fasting blood sugar, lipid profile, and serum ferritin.
Deteriorated hematological and biochemical statuses were reported in both males and females of βTM patients as compared to the control group. Statistical comparisons showed no significant differences between males and females βTM patients in all parameters except for total cholesterol. The results concerning the splenectomized versus non-splenectomized patients revealed significantly higher values in splenectomized patients for white blood cell (WBC), platelet, aspartate aminotransferase, alanine aminotransferase, alkaline phosphatase, albumin, total protein, cholesterol, and potassium concentration compared to the non-splenectomized patients. Patients infected with hepatitis C virus and/or hepatitis B virus showed significant decrease in WBC count as compared to infection free patients, while for serum urea and creatinine, the virally infected βTM patients revealed significantly higher values compared to infection free patients.
This study justified the necessity for strengthening the efforts for regular evaluation and follow-up of the βTM patients which could be used to improve or modify the management protocols and thus ameliorating their deteriorated hematological and biochemical status.
在巴勒斯坦加沙地带，β地中海贫血是一个重大的公共卫生问题，目前有300多名重型β地中海贫血（βTM）患者在政府医院接受治疗。我们着手评估加沙欧洲医院βTM患者的血液学和生化指标及其与铁过载的相关性。
我们的研究纳入了65名依赖输血的βTM患者以及37名健康受试者作为对照组。血液学和生化评估包括全血细胞计数、凝血指标、肝肾功能检查、空腹血糖、血脂谱和血清铁蛋白。
与对照组相比，βTM患者的男性和女性血液学和生化指标均有所恶化。统计比较显示，除总胆固醇外，βTM患者的男性和女性在所有参数上均无显著差异。脾切除患者与未脾切除患者的结果显示，脾切除患者的白细胞（WBC）、血小板、天冬氨酸转氨酶、丙氨酸转氨酶、碱性磷酸酶、白蛋白、总蛋白、胆固醇和钾浓度均显著高于未脾切除患者。与未感染患者相比，感染丙型肝炎病毒和/或乙型肝炎病毒的患者白细胞计数显著降低，而对于血清尿素和肌酐，病毒感染的βTM患者的数值显著高于未感染患者。
本研究证明有必要加强对βTM患者进行定期评估和随访的工作，这可用于改进或调整管理方案，从而改善其恶化的血液学和生化指标。
