Khawaji Mohammed Mansour, Hazzazi Ahmad Ali, Ageeli Mohssen Hassen, Mawkili Yahya Hassan, Darbashi Abdulrahman Hussain, Abo Kathiyah Anwar Mohammed Ali, Humedi Rehab Abdalrhman
Faculty of Medicine, Jazan University, Jazan, Saudi Arabia.
J Family Med Prim Care. 2020 Jan 28;9(1):412-417. doi: 10.4103/jfmpc.jfmpc_1007_19. eCollection 2020 Jan.
Beta-thalassemia is a prevalent hereditary blood disorder in Saudi Arabia. Various clinical manifestations and hematological abnormalities are common among these patients.
To evaluate the clinical manifestations and hematological parameters of β-thalassemia patients in Jazan, Saudi Arabia.
This is a cross-sectional study conducted in Jazan region, Saudi Arabia.
We included 36 β-Thalassemia major patients who admitted to PMNH during the period from February 1, 2016 to December 31, 2017. Clinical features were obtained via physical examination. The hematological parameters were obtained from the patients' medical records.
Descriptive and inferential statistics were conducted using SPSS. Continuous data was evaluated using independent sample -test and Chi-square was used to evaluate categorical variables. < 0.05 indicated statistical significance.
Mean age was 18.56 ± 6.89 years. Males were 23 (63.9%). About 41.4% of patients were underweight. Exposing of the upper teeth was the most prominent feature ( = 19, 59.4%). The majority of patients were splenectomized (62.1%). About two-thirds have moderate anemia. More than half of the patients (58.8%) had high WBCs counts and 35.3% had a high platelet count, especially among those who underwent splenectomy. Approximately, two-thirds had a ferritin level higher than 2500 ng/ml. O blood group was the most frequent blood group among the patients ( = 15, 46.9%).
Deteriorated clinical and hematological parameters in our study justify the need for more efforts for regular evaluation and follow-up of the βTM patients and reevaluation of the management protocols to be improved or modified.
β地中海贫血是沙特阿拉伯一种常见的遗传性血液疾病。这些患者中各种临床表现和血液学异常很常见。
评估沙特阿拉伯吉赞地区β地中海贫血患者的临床表现和血液学参数。
这是一项在沙特阿拉伯吉赞地区进行的横断面研究。
我们纳入了2016年2月1日至2017年12月31日期间入住PMNH的36例重型β地中海贫血患者。通过体格检查获得临床特征。血液学参数从患者的病历中获取。
使用SPSS进行描述性和推断性统计。连续数据使用独立样本t检验进行评估，卡方检验用于评估分类变量。P<0.05表示具有统计学意义。
平均年龄为18.56±6.89岁。男性有23例（63.9%）。约41.4%的患者体重过轻。上牙外露是最突出的特征（n = 19，59.4%）。大多数患者接受了脾切除术（62.1%）。约三分之二的患者有中度贫血。超过一半的患者（58.8%）白细胞计数高，35.3%的患者血小板计数高，尤其是在接受脾切除术的患者中。大约三分之二的患者铁蛋白水平高于2500 ng/ml。O血型是患者中最常见的血型（n = 15，46.9%）。
我们研究中临床和血液学参数的恶化证明需要加大力度对重型β地中海贫血患者进行定期评估和随访，并重新评估管理方案以进行改进或修改。
