Al-Azzawi Issam S, Al-Tamimi Mohamed A J
Department of Urology, Al-Mustansiriya University, Baghdad, Iraq.
Department of Neurosurgery, Al-Mustansiriya University, Baghdad, Iraq.
Arab J Urol. 2018 Aug 7;16(4):391-396. doi: 10.1016/j.aju.2018.05.006. eCollection 2018 Dec.
To present our experience, in Iraq, with sacral neuromodulation (SNM) in patients with refractory lower urinary tract dysfunction, with discussion of the factors that affect the response rate.
In this prospective, clinical, interventional study, 24 patients were evaluated and treated by a team comprised of a Urologist and a Neurosurgeon with SNM over a 1.5-year period. The gender, age, pathology, and clinical presentation, were all studied and evaluated. Successful clinical response was defined as achieving a ≥50% improvement in voiding diary variables.
The mean age of those that responded to SNM was 28 years, with females responding better than males (10 of 14 vs four of 10). The SNM response rate according to presentation was six of 10 in those with overactive bladder/urge urinary incontinence, six of nine of those with urinary retention, and two of five in those with a mixed presentation. The response rate in idiopathic voiding dysfunctions was 11 of 13, whilst for neurogenic dysfunctions it was three of 11. Other benefits such as in bowel motion, erectile function, menstruation, power of lower limbs, and quality of life (QoL), were also recorded. The complications were reasonable for this minimally invasive procedure.
SNM offers a good and durable solution for some functional bladder problems, if patients are well selected. There may also be additional extra-urinary benefits that contribute to improvements in QoL. SNM was well tolerated by our patients with an encouraging response rate, especially in psychologically stable patients with idiopathic dysfunctions.
介绍我们在伊拉克对难治性下尿路功能障碍患者进行骶神经调节(SNM)的经验,并讨论影响有效率的因素。
在这项前瞻性临床干预研究中,一个由泌尿外科医生和神经外科医生组成的团队在1.5年的时间里对24例患者进行了评估和SNM治疗。对患者的性别、年龄、病理情况和临床表现进行了研究和评估。成功的临床反应定义为排尿日记变量改善≥50%。
对SNM有反应的患者平均年龄为28岁,女性的反应优于男性(14例中的10例 vs 10例中的4例)。根据临床表现,膀胱过度活动症/急迫性尿失禁患者中SNM有效率为10例中的6例,尿潴留患者中9例中的6例,混合性表现患者中5例中的2例。特发性排尿功能障碍的有效率为13例中的11例,而神经源性功能障碍的有效率为11例中的3例。还记录了其他益处,如排便、勃起功能、月经、下肢力量和生活质量(QoL)。对于这种微创手术来说,并发症在合理范围内。
如果患者选择得当,SNM为一些功能性膀胱问题提供了良好且持久的解决方案。可能还有额外的泌尿外益处有助于改善生活质量。我们的患者对SNM耐受性良好,有效率令人鼓舞,尤其是心理稳定的特发性功能障碍患者。