Strecke J, Oettel M
Endocrinol Exp. 1977 Dec;11(4):277-84.
Male and female rats aged 3 days were injected intragastrically with methyltestosterone and STS 383 synthetic androgen in doses between 0.4-3.2 mg and 0.2-3.2 mg, respectively. The treated females showed disturbances in hypothalamic differentiation as demonstrated by changes of the day of vaginal opening and frequency of oestrus, by a decrease of ovarian weight and a loss of fertility. It is thus possible to investigate perorally active aromatizable androgens for their central activities. STS 383, a new p. o. active androgen showed a higher activity compared with methyltestosterone in this study, whereas in the Hershberger model methyltestosterone was previously found to be 4 times more active than STS 383. A possible dissociation of central and peripheral activities between these two substances is discussed.
给3日龄的雄性和雌性大鼠分别经胃内注射剂量在0.4 - 3.2毫克和0.2 - 3.2毫克之间的甲基睾酮和STS 383合成雄激素。经处理的雌性大鼠表现出下丘脑分化紊乱，这通过阴道开口时间和发情频率的变化、卵巢重量的降低以及生育能力的丧失得以证明。因此，有可能对口服活性可芳香化雄激素的中枢活性进行研究。在本研究中，一种新型口服活性雄激素STS 383与甲基睾酮相比表现出更高的活性，而在赫什伯格模型中，先前发现甲基睾酮的活性比STS 383高4倍。讨论了这两种物质中枢和外周活性可能的解离情况。
