用于测量啮齿动物焦虑样行为的高架十字迷宫试验。
The Elevated Plus Maze Test for Measuring Anxiety-Like Behavior in Rodents.
作者信息
Kraeuter Ann-Katrin, Guest Paul C, Sarnyai Zoltán
机构信息
Laboratory of Psychiatric Neuroscience, Australian Institute of Tropical Health and Medicine, James Cook University, Townsville, QLD, Australia.
Discipline of Biomedicine, College of Public Health, Medicine and Veterinary Sciences, James Cook University, Townsville, QLD, Australia.
出版信息
Methods Mol Biol. 2019;1916:69-74. doi: 10.1007/978-1-4939-8994-2_4.
The elevated plus maze test is used to measure anxiety-like behavior in rodents. It can be used to gain insight into conditions such as posttraumatic stress disorder (PTSD) and other conditions marked by anxious behavior. It can also be used as a component in screening of novel compounds for anxiolytic properties. This model is based on aversion to open spaces, which is seen as the animal spending more time in the enclosed arms of the maze. This chapter describes the steps necessary for setting up and conducting the test, along with interpretation of the results.
高架十字迷宫试验用于测量啮齿动物的焦虑样行为。它可用于深入了解创伤后应激障碍（PTSD）等病症以及其他以焦虑行为为特征的病症。它还可作为筛选具有抗焦虑特性的新型化合物的一个组成部分。该模型基于对开放空间的厌恶，表现为动物在迷宫的封闭臂中停留的时间更长。本章介绍了设置和进行该试验所需的步骤以及结果解读。
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