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Successful treatment of ETV6-NTRK3 fusion gene-negative infantile fibrosarcoma with metastatic lesion resistant to VAC chemotherapy.

作者信息

Moriya Kunihiko, Abe Sei, Onuma Masaei, Sato Atsushi, Takeyama Junji, Hosaka Masami, Sasahara Yoji, Imaizumi Masue

机构信息

Department of Hematology and Oncology, Miyagi Children's Hospital, Sendai, Miyagi, Japan.

Department of Pediatrics, Tohoku University Graduate School of Medicine, Sendai, Miyagi, Japan.

出版信息

Pediatr Int. 2018 Nov;60(11):1045-1046. doi: 10.1111/ped.13704.

DOI:10.1111/ped.13704
PMID:30536487
Abstract
摘要

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Successful treatment of ETV6-NTRK3 fusion gene-negative infantile fibrosarcoma with metastatic lesion resistant to VAC chemotherapy.成功治疗对VAC化疗耐药且伴有转移灶的ETV6-NTRK3融合基因阴性婴儿纤维肉瘤。
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Rapid, complete and sustained tumour response to the TRK inhibitor larotrectinib in an infant with recurrent, chemotherapy-refractory infantile fibrosarcoma carrying the characteristic ETV6-NTRK3 gene fusion.婴儿复发性、化疗耐药性婴儿纤维肉瘤携带特征性 ETV6-NTRK3 基因融合，对 TRK 抑制剂拉罗替尼快速、完全和持续的肿瘤应答。
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A novel ETV6-NTRK3 gene fusion in congenital fibrosarcoma.先天性纤维肉瘤中的一种新型ETV6-NTRK3基因融合
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Marginal resection as a potential curative treatment option of infantile fibrosarcoma with good response after chemotherapy: A case report of an ETV6-NTRK3 positive infantile fibrosacroma of the distal tibia.边缘切除术作为婴儿纤维肉瘤潜在的治愈性治疗选择，化疗后反应良好：一例 ETv6-NTRK3 阳性的胫骨远端婴儿纤维肉瘤的病例报告。
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Non-resectable congenital tumors with the ETV6-NTRK3 gene fusion are highly responsive to chemotherapy.具有ETV6-NTRK3基因融合的不可切除先天性肿瘤对化疗高度敏感。
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Unusual localization and aggressive progression of large infantile fibrosarcoma.巨大婴儿纤维肉瘤的不寻常定位和侵袭性进展
Acta Orthop Traumatol Turc. 2019 Nov;53(6):507-511. doi: 10.1016/j.aott.2019.08.008. Epub 2019 Sep 11.