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内镜鼻窦手术的等待时间会影响符合适宜性标准的慢性鼻-鼻窦炎患者的患者报告结局测量。

Wait times for endoscopic sinus surgery influence patient-reported outcome measures in patients with chronic rhinosinusitis who fulfill appropriateness criteria.

机构信息

Division of Rhinology, Department of Otolaryngology-Head and Neck Surgery, St. Michael's Hospital, University of Toronto, Toronto, ON, Canada.

Division of Head and Neck Oncology, Department of Otolaryngology-Head and Neck Surgery, Sunnybrook Health Sciences Centre and Michael Garron Hospital, University of Toronto, Toronto, ON, Canada.

出版信息

Int Forum Allergy Rhinol. 2019 Apr;9(4):396-401. doi: 10.1002/alr.22257. Epub 2018 Dec 10.

Abstract

BACKGROUND

Previous studies on the impact of wait times for endoscopic sinus surgery (ESS) in medically recalcitrant chronic rhinosinusitis (rCRS) have not examined its influence on the 5 distinct symptoms domains of the 22-item Sino-Nasal Outcome Test (SNOT-22), and have not applied evidence-based surgical indications. Our primary study objective was to investigate the impact of ESS wait times on postoperative SNOT-22 global and symptom domain scores in patients with rCRS deemed "appropriate" surgical candidates.

METHODS

This was a retrospective analysis of adult patients with rCRS undergoing ESS, categorized as "appropriate" surgical candidates. Primary outcome measure was change in SNOT-22 global/symptom domain score (preoperative - 6-month postoperative). Correlational analyses were performed between wait time and change in SNOT-22 global and symptom domain scores. For significant negative correlations, the threshold wait time to generate a worsening in health-related quality-of-life (HRQoL) equivalent to the mean clinically important difference (MCID) was calculated.

RESULTS

A total of 104 patients with a mean ± standard deviation (SD) wait time of 310.8 ± 155.9 days were analyzed. Postoperative SNOT-22 global and symptom domain scores significantly improved postoperatively. Wait time for ESS was negatively correlated with change in SNOT-22 global, rhinologic, extranasal rhinologic, and ear/facial domain scores (p < 0.05), and a wait time threshold of 287, 452, 421, and 381 days corresponded to a decrease equivalent to the MCID, respectively.

CONCLUSION

We identified less improvement in HRQoL after ESS with increasing surgical wait time. Moreover, prolonged wait times may result in less improvement in disease-specific symptoms, but do not appear to worsen psychological or sleep dysfunction.

摘要

背景

先前关于内镜鼻窦手术(ESS)等待时间对医学上难治性慢性鼻-鼻窦炎(rCRS)的影响的研究,并未检查其对 22 项鼻-鼻窦结局测试(SNOT-22)的 5 个不同症状域的影响,也未应用循证手术指征。我们的主要研究目的是研究 ESS 等待时间对被认为是“合适”手术候选者的 rCRS 患者术后 SNOT-22 总体和症状域评分的影响。

方法

这是一项对接受 ESS 的 rCRS 成年患者的回顾性分析,分为“合适”手术候选者。主要观察指标是 SNOT-22 总体/症状域评分的变化(术前-6 个月术后)。对等待时间与 SNOT-22 总体和症状域评分变化之间的相关性进行了相关性分析。对于显著的负相关,计算了产生与平均临床重要差异(MCID)相当的健康相关生活质量(HRQoL)恶化的阈值等待时间。

结果

共分析了 104 例患者,平均(±标准差)等待时间为 310.8±155.9 天。术后 SNOT-22 总体和症状域评分明显改善。ESS 的等待时间与 SNOT-22 总体、鼻科学、鼻外鼻科学和耳/面部域评分的变化呈负相关(p<0.05),等待时间阈值分别为 287、452、421 和 381 天,相当于 MCID 的降低。

结论

我们发现随着手术等待时间的增加,HRQoL 的改善减少。此外,延长等待时间可能导致疾病特异性症状改善减少,但似乎不会恶化心理或睡眠功能障碍。

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