Division of Rhinology, Department of Otolaryngology-Head and Neck Surgery, St. Michael's Hospital, University of Toronto, Toronto, ON, Canada.
Division of Head and Neck Oncology, Department of Otolaryngology-Head and Neck Surgery, Sunnybrook Health Sciences Centre and Michael Garron Hospital, University of Toronto, Toronto, ON, Canada.
Int Forum Allergy Rhinol. 2019 Apr;9(4):396-401. doi: 10.1002/alr.22257. Epub 2018 Dec 10.
Previous studies on the impact of wait times for endoscopic sinus surgery (ESS) in medically recalcitrant chronic rhinosinusitis (rCRS) have not examined its influence on the 5 distinct symptoms domains of the 22-item Sino-Nasal Outcome Test (SNOT-22), and have not applied evidence-based surgical indications. Our primary study objective was to investigate the impact of ESS wait times on postoperative SNOT-22 global and symptom domain scores in patients with rCRS deemed "appropriate" surgical candidates.
This was a retrospective analysis of adult patients with rCRS undergoing ESS, categorized as "appropriate" surgical candidates. Primary outcome measure was change in SNOT-22 global/symptom domain score (preoperative - 6-month postoperative). Correlational analyses were performed between wait time and change in SNOT-22 global and symptom domain scores. For significant negative correlations, the threshold wait time to generate a worsening in health-related quality-of-life (HRQoL) equivalent to the mean clinically important difference (MCID) was calculated.
A total of 104 patients with a mean ± standard deviation (SD) wait time of 310.8 ± 155.9 days were analyzed. Postoperative SNOT-22 global and symptom domain scores significantly improved postoperatively. Wait time for ESS was negatively correlated with change in SNOT-22 global, rhinologic, extranasal rhinologic, and ear/facial domain scores (p < 0.05), and a wait time threshold of 287, 452, 421, and 381 days corresponded to a decrease equivalent to the MCID, respectively.
We identified less improvement in HRQoL after ESS with increasing surgical wait time. Moreover, prolonged wait times may result in less improvement in disease-specific symptoms, but do not appear to worsen psychological or sleep dysfunction.
先前关于内镜鼻窦手术(ESS)等待时间对医学上难治性慢性鼻-鼻窦炎(rCRS)的影响的研究,并未检查其对 22 项鼻-鼻窦结局测试(SNOT-22)的 5 个不同症状域的影响,也未应用循证手术指征。我们的主要研究目的是研究 ESS 等待时间对被认为是“合适”手术候选者的 rCRS 患者术后 SNOT-22 总体和症状域评分的影响。
这是一项对接受 ESS 的 rCRS 成年患者的回顾性分析,分为“合适”手术候选者。主要观察指标是 SNOT-22 总体/症状域评分的变化(术前-6 个月术后)。对等待时间与 SNOT-22 总体和症状域评分变化之间的相关性进行了相关性分析。对于显著的负相关,计算了产生与平均临床重要差异(MCID)相当的健康相关生活质量(HRQoL)恶化的阈值等待时间。
共分析了 104 例患者,平均(±标准差)等待时间为 310.8±155.9 天。术后 SNOT-22 总体和症状域评分明显改善。ESS 的等待时间与 SNOT-22 总体、鼻科学、鼻外鼻科学和耳/面部域评分的变化呈负相关(p<0.05),等待时间阈值分别为 287、452、421 和 381 天,相当于 MCID 的降低。
我们发现随着手术等待时间的增加,HRQoL 的改善减少。此外,延长等待时间可能导致疾病特异性症状改善减少,但似乎不会恶化心理或睡眠功能障碍。