寡转移PD-L1阳性鼻咽癌患者对一线纳武单抗的持久反应。 - Suppr

Durable response to first-line nivolumab in a patient with oligometastatic PD-L1 positive nasopharyngeal cancer.

作者信息

Cabezas-Camarero S, Puebla F, Subhi-Issa A I, Sanz-Ortega J, Pérez-Segura Pedro

机构信息

Medical Oncology Department, Hospital Clínico Universitario San Carlos, Instituto de Investigación Sanitaria San Carlos (IdISSC), Madrid, Spain(1).

Radiation Oncology Department, Hospital Clínico Universitario San Carlos, Madrid, Spain.

出版信息

Oral Oncol. 2018 Dec;87:204-206. doi: 10.1016/j.oraloncology.2018.10.019. Epub 2018 Oct 25.

DOI:10.1016/j.oraloncology.2018.10.019

PMID:30539728

Abstract

摘要

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Durable response to first-line nivolumab in a patient with oligometastatic PD-L1 positive nasopharyngeal cancer.寡转移PD-L1阳性鼻咽癌患者对一线纳武单抗的持久反应。

Oral Oncol. 2018 Dec;87:204-206. doi: 10.1016/j.oraloncology.2018.10.019. Epub 2018 Oct 25.

Successful treatment with nivolumab for lung cancer with low expression of PD-L1 and prominent tumor-infiltrating B cells and immunoglobulin G.尼伏鲁单抗治疗 PD-L1 低表达且肿瘤浸润 B 细胞和免疫球蛋白 G 明显的肺癌取得成功。

Thorac Cancer. 2018 Jun;9(6):750-753. doi: 10.1111/1759-7714.12644. Epub 2018 Apr 18.

Positive Conversion of PD-L1 Expression After Treatments with Chemotherapy and Nivolumab.化疗和纳武单抗治疗后PD-L1表达的阳性转化

Anticancer Res. 2017 Oct;37(10):5713-5717. doi: 10.21873/anticanres.12009.

Dramatic Antitumor Activity of Nivolumab in Advanced HER2-Positive Lung Cancer.纳武单抗对晚期HER2阳性肺癌具有显著的抗肿瘤活性。

Clin Lung Cancer. 2016 Sep;17(5):e179-e183. doi: 10.1016/j.cllc.2016.05.004. Epub 2016 Jun 4.

A Long-term Response to Nivolumab in a Case of PD-L1-negative Lung Adenocarcinoma with an EGFR Mutation and Surrounding PD-L1-positive Tumor-associated Macrophages.一例伴有EGFR突变及周围PD-L1阳性肿瘤相关巨噬细胞的PD-L1阴性肺腺癌患者对纳武单抗的长期反应

Intern Med. 2019 Oct 15;58(20):3033-3037. doi: 10.2169/internalmedicine.2875-19. Epub 2019 Jul 10.

Whole body PD-1 and PD-L1 positron emission tomography in patients with non-small-cell lung cancer.全身 PD-1 和 PD-L1 正电子发射断层扫描在非小细胞肺癌患者中的应用。

Nat Commun. 2018 Nov 7;9(1):4664. doi: 10.1038/s41467-018-07131-y.

Co-expression of PD-1 and PD-L1 predicts poor outcome in nasopharyngeal carcinoma.PD-1与PD-L1的共表达预示着鼻咽癌的不良预后。

Med Oncol. 2015 Mar;32(3):86. doi: 10.1007/s12032-015-0501-6. Epub 2015 Feb 22.

PD-L1 expression in circulating tumor cells of advanced non-small cell lung cancer patients treated with nivolumab.纳武利尤单抗治疗晚期非小细胞肺癌患者循环肿瘤细胞中 PD-L1 的表达。

Lung Cancer. 2018 Jun;120:108-112. doi: 10.1016/j.lungcan.2018.04.001. Epub 2018 Apr 3.

[Successful Treatment of Squamous Cell Lung Cancer without PD-L1 Expression Using Fourth-Line Nivolumab].[使用四线纳武单抗成功治疗无PD-L1表达的肺鳞状细胞癌]

Gan To Kagaku Ryoho. 2019 May;46(5):917-920.

Complete Response Achieved 1 Year after a Single Administration of Nivolumab in a Patient with Lung Adenocarcinoma with Negative Expression of PD-L1.在一名PD-L1表达阴性的肺腺癌患者单次使用纳武利尤单抗后1年实现完全缓解。

J Thorac Oncol. 2017 Dec;12(12):e205-e207. doi: 10.1016/j.jtho.2017.08.017.

引用本文的文献

Current Immune-Related Molecular Approach in Combating Nasopharyngeal Cancer.当前对抗鼻咽癌的免疫相关分子方法。

World J Oncol. 2019 Oct;10(4-5):157-161. doi: 10.14740/wjon1214. Epub 2019 Sep 20.

Real-World Outcomes and Prognostic Factors in Patients Receiving Nivolumab Therapy for Recurrent or Metastatic Head and Neck Carcinoma.接受纳武利尤单抗治疗的复发性或转移性头颈癌患者的真实世界结局及预后因素

Cancers (Basel). 2019 Sep 6;11(9):1317. doi: 10.3390/cancers11091317.

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Durable response to first-line nivolumab in a patient with oligometastatic PD-L1 positive nasopharyngeal cancer.

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