器官纤维化的解决机制。
Mechanisms for the Resolution of Organ Fibrosis.
机构信息
Department of Internal Medicine, Division of Pulmonary and Critical Care Medicine, University of Michigan Medical School , Ann Arbor, Michigan.
Department of Medicine, Division of Pulmonary, Allergy and Critical Care Medicine, University of Alabama at Birmingham , Birmingham, Alabama.
出版信息
Physiology (Bethesda). 2019 Jan 1;34(1):43-55. doi: 10.1152/physiol.00033.2018.
Abstract
Fibrosis is a dynamic process with the potential for reversibility and restoration of near-normal tissue architecture and organ function. Herein, we review mechanisms for resolution of organ fibrosis, in particular that involving the lung, with an emphasis on the critical roles of myofibroblast apoptosis and clearance of deposited matrix.
摘要
纤维化是一个动态过程，具有逆转和恢复组织形态和器官功能接近正常的潜力。在此，我们综述了器官纤维化消退的机制，特别是涉及肺的纤维化消退机制，重点强调肌成纤维细胞凋亡和沉积基质清除的关键作用。
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