J Org Chem. 2019 Jan 4;84(1):435-442. doi: 10.1021/acs.joc.8b02680. Epub 2018 Dec 26.
A novel and efficient direct oxidative phosphonylation of α-amino ketones and α-amino acid derivatives with dialkyl phosphites by the catalysis of a cobalt salt under air is disclosed. A variety of α-amino ketones and α-amino acid derivatives underwent the reaction well with dialkyl phosphites to produce the desired α-aminophosphonates. This protocol not only provides an alternative synthetic route for the preparation of diverse α-aminophosphonates but also avoids the use of potentially explosive peroxide agents.
本文公开了一种钴盐催化下在空气中通过二烷基膦酸酯对α-氨基酮和α-氨基酸衍生物的新型高效直接氧化膦酰化反应。各种α-氨基酮和α-氨基酸衍生物与二烷基膦酸酯反应良好，生成所需的α-氨基膦酸酯。该方案不仅为制备各种α-氨基膦酸酯提供了另一种合成途径，而且避免了使用潜在爆炸性的过氧化物试剂。
