β-受体阻滞剂在严重脓毒症和脓毒性休克中的血流动力学反应：文献复习。
Hemodynamic response to β-blockers in severe sepsis and septic shock: A review of current literature.
机构信息
Biomedical Signals and Systems, Faculty of Electrical Engineering, Mathematics and Computer Science, Technical Medical Centre, University of Twente, Postbox 217, 7500 AE Enschede, the Netherlands; Department of Critical Care Medicine (707), Radboud university medical center, PO Box 9101, 6500 HB Nijmegen, the Netherlands.
Department of Critical Care Medicine (707), Radboud university medical center, PO Box 9101, 6500 HB Nijmegen, the Netherlands.
出版信息
J Crit Care. 2019 Apr;50:138-143. doi: 10.1016/j.jcrc.2018.12.003. Epub 2018 Dec 5.
The administration of β-blockers in patients with sepsis is a trending topic in intensive care medicine since the landmark study by Morelli and colleagues, showing a striking decrease in 28-day mortality compared to standard care. While the available evidence suggests that the use of β-blockers in septic shock is safe, the effects on hemodynamics are controversial. In this paper, we review the effect of β-blockade in septic shock on hemodynamics from animal models to critically ill patients.
在脓毒症患者中使用β受体阻滞剂是重症医学领域的一个热门话题，这源于 Morelli 等人的里程碑式研究，该研究表明与标准治疗相比，β受体阻滞剂可显著降低 28 天死亡率。尽管现有证据表明在感染性休克中使用β受体阻滞剂是安全的，但对血流动力学的影响仍存在争议。本文从动物模型到危重症患者，综述了β受体阻滞剂对感染性休克血流动力学的影响。
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