女性职业性多环芳烃暴露与乳腺癌风险。
Women's occupational exposure to polycyclic aromatic hydrocarbons and risk of breast cancer.
机构信息
Cancer Control Research, BC Cancer, Vancouver, British Columbia, Canada.
Department of Mathematics, Statistics, and Computer Science, St. Francis Xavier University, Antigonish, Nova Scotia, Canada.
出版信息
Occup Environ Med. 2019 Jan;76(1):22-29. doi: 10.1136/oemed-2018-105261.
OBJECTIVE
To estimate the association between occupational polycyclic aromatic hydrocarbon (PAH) exposure and female breast cancer.
METHODS
Lifetime work histories for 1130 cases and 1169 controls from British Columbia and Ontario (Canada) were assessed for PAH exposure using a job-exposure matrix based on compliance measurements obtained during US Occupational Safety and Health Administration workplace safety inspections.
RESULTS
Exposure to any level of PAHs was associated with an increased risk of breast cancer (OR=1.32, 95% CI: 1.10 to 1.59), as was duration at high PAH exposure (for >7.4 years: OR=1.45, 95% CI: 1.10 to 1.91; p=0.01), compared with women who were never exposed. Increased risk of breast cancer was most strongly associated with prolonged duration at high occupational PAH exposure among women with a family history of breast cancer (for >7.4 years: OR=2.79, 95% CI: 1.25 to 6.24; p<0.01).
CONCLUSIONS
Our study suggests that prolonged occupational exposure to PAH may increase breast cancer risk, especially among women with a family history of breast cancer.
目的
评估职业多环芳烃（PAH）暴露与女性乳腺癌之间的关联。
方法
对来自不列颠哥伦比亚省和安大略省（加拿大）的 1130 例病例和 1169 例对照的终生工作史进行了评估，使用了基于美国职业安全与健康管理局工作场所安全检查期间获得的合规性测量值的职业暴露矩阵来评估 PAH 暴露情况。
结果
任何程度的 PAH 暴露都与乳腺癌风险增加相关（OR=1.32，95%CI：1.10 至 1.59），与从未暴露的女性相比，高 PAH 暴露持续时间较长（>7.4 年：OR=1.45，95%CI：1.10 至 1.91；p=0.01）。与乳腺癌家族史的女性相比，高职业 PAH 暴露持续时间较长与乳腺癌风险增加的相关性最强（>7.4 年：OR=2.79，95%CI：1.25 至 6.24；p<0.01）。
结论
我们的研究表明，职业性多环芳烃暴露时间延长可能会增加乳腺癌风险，尤其是有乳腺癌家族史的女性。
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