工作环境与骨髓增殖性肿瘤：一项基于人群的病例对照研究及群组调查
Working environment and myeloproliferative neoplasm: A population-based case-control study following a cluster investigation.
作者信息
Heavner Karyn, Gross-Davis Carol Ann, Frank Arthur L, Newschaffer Craig, Klotz Judith, Burstyn Igor
机构信息
Department of Environmental and Occupational Health, Drexel University, Philadelphia, Pennsylvania.
Environmental Protection Agency, Region 3, Philadelphia, Pennsylvania.
出版信息
Am J Ind Med. 2015 Jun;58(6):595-604. doi: 10.1002/ajim.22451. Epub 2015 Apr 16.
BACKGROUND
Occupational exposures, including those to polycyclic aromatic hydrocarbons (PAH), are suspected risk factors for myeloproliferative neoplasms (MPN).
METHODS
We investigated occupational exposures and MPN risk (54 cases and 472 controls) in a population-based case-control study in three rural Pennsylvania counties. Occupational histories, coded to SIC/SOC 1980, were linked to a previously created PAH job-exposure matrix. Odds ratios for industry (17 categories), occupation (26 categories), and PAH exposure were adjusted using logistic regression.
RESULTS
No industries or occupations were strongly or consistently associated with increased MPN risk. Analysis of employment duration found that being employed for 5 or more years in transportation, communications, and other public utilities was associated with MPN risk. There was no indication of an association with cumulative PAH exposure.
CONCLUSIONS
These few associations did not appear to have a common exposure. This exploratory study does not support the hypothesis that occupational exposure, including PAH, are strong risk factors for MPNs.
背景
职业暴露，包括多环芳烃（PAH）暴露，被怀疑是骨髓增殖性肿瘤（MPN）的风险因素。
方法
在宾夕法尼亚州三个农村县进行的一项基于人群的病例对照研究中，我们调查了职业暴露与MPN风险（54例病例和472例对照）。按照1980年的标准产业分类/标准职业分类编码的职业史与先前创建的PAH职业暴露矩阵相关联。使用逻辑回归对行业（17类）、职业（26类）和PAH暴露的比值比进行调整。
结果
没有行业或职业与MPN风险增加有强烈或持续的关联。对就业时长的分析发现，在运输、通信和其他公共事业领域工作5年或更长时间与MPN风险相关。没有迹象表明与累积PAH暴露有关联。
结论
这些少数关联似乎没有共同的暴露因素。这项探索性研究不支持职业暴露（包括PAH暴露）是MPN的强风险因素这一假设。
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