Sun Shiming, Wang Fengli, Yu Miao, Kang Jing
Clinical Laboratory, The Third Affiliated Hospital of Qiqihar Medical University, Qiqihar, Heilongjiang 161000, P.R. China.
Clinical Laboratory, Dalian Municipal Central Hospital, Dalian, Liaoning 116033, P.R. China.
Exp Ther Med. 2018 Dec;16(6):5210-5214. doi: 10.3892/etm.2018.6841. Epub 2018 Oct 9.
This study determined the serum procalcitonin (PCT) levels in patients with myocardial infarction complicated by pulmonary infection and explore its clinical significance and diagnostic value. A total of 473 patients who were admitted to the Third Affiliated Hospital of Qiqihar Medical University from January 2016 to June 2017 were enrolled as research subjects. Patients were divided into four groups based on their symptom status in myocardial infarction and pulmonary infection. There were 109 patients in normal control group who did not experience symptoms of either myocardial infarction or pulmonary infection. Blood samples were collected from each patient, and PCT levels were measured. The data were analyzed. The serum PCT levels prior to treatment were compared with each other. The PCT levels in the myocardial infarction and the pulmonary infection group were all higher than that in the normal control group (0.040±0.015) (p<0.05). On the contrary, the serum PCT level in the myocardial infarction complicated by pulmonary infection group was higher than that in the normal control group (p<0.001). The serum PCT level after treatment was compared with that before treatment within the same group. The serum PCT levels in the three disease groups were comparable after treatment. The differences in PCT levels before and after treatment were all statistically significant within all three groups (p<0.05). A patient's serum PCT level was correlated with myocardial infarction complicated by pulmonary infection, which suggested it can be used as an important diagnostic marker for this complication. This finding has important clinical value for predicting and evaluating the complicated condition of myocardial infarction and pulmonary infection by providing a more accurate, sensitive, and specific method for early diagnosis of the disease.
本研究测定了心肌梗死合并肺部感染患者的血清降钙素原(PCT)水平,并探讨其临床意义及诊断价值。选取2016年1月至2017年6月在齐齐哈尔医学院附属第三医院住院的473例患者作为研究对象。根据患者心肌梗死及肺部感染的症状情况分为四组。正常对照组109例,无心肌梗死及肺部感染症状。采集每位患者的血样,检测PCT水平,并进行数据分析。比较治疗前各组血清PCT水平。心肌梗死组及肺部感染组的PCT水平均高于正常对照组(0.040±0.015)(p<0.05)。相反,心肌梗死合并肺部感染组血清PCT水平高于正常对照组(p<0.001)。比较同组治疗前后血清PCT水平。治疗后三个疾病组的血清PCT水平相近。三组治疗前后PCT水平差异均有统计学意义(p<0.05)。患者血清PCT水平与心肌梗死合并肺部感染相关,提示其可作为该并发症的重要诊断标志物。这一发现为心肌梗死合并肺部感染的病情预测及评估提供了更准确、敏感和特异的早期诊断方法,具有重要的临床价值。