sTREM-1、PCT 和 1,3-β-D 葡聚糖在免疫相关性肺间质疾病合并真菌感染中的诊断价值。

Clinical Value of sTREM-1, PCT, and 1,3--D Glucan in Diagnosis of Immune-Associated Pulmonary Interstitial Disease with Fungal Infection.

机构信息

Department of Rheumatology and Immunology, Tianjin First Central Hospital, Tianjin 300192, China.

出版信息

Biomed Res Int. 2022 Jul 27;2022:6095441. doi: 10.1155/2022/6095441. eCollection 2022.

DOI:10.1155/2022/6095441

PMID:35937405

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9348935/

Abstract

BACKGROUND

Fungal infection in the lungs can cause fungal infectious diseases. This disease develops rapidly and involves a wide range. Pathogenic fungi are also more serious types of pathogenic bacteria. If it invades deep organs and tissues, it will endanger life, so it needs timely diagnosis.

AIM

To investigate the diagnostic value of serum soluble myeloid cell triggering receptor-1 (sTREM-1), procalcitonin (PCT), and 1,3--D glucan detection in immune related lung disease complicated with fungal infection.

METHODS

In this study, a case-control study was conducted. 50 patients with immune-related pulmonary disease complicated with fungal infection (infection group) diagnosed by sputum culture in our hospital from January 2017 to December 2021 were selected as the control group, and 50 patients with immune-related pulmonary disease without fungal infection were selected as the control group. The levels of sTREM-1, PCT, and 1,3--D glucan were compared in the two groups. The receiver operating characteristic (ROC) was used to analyze the value of the three indicators in the diagnosis of immune-related pulmonary disease complicated with fungal infection, and the changes of the three indicators before and after treatment were compared.

RESULTS

The levels of sTREM-1, PCT, and 1,3--D glucan in the infection group were higher than those in the control group ( < 0.05). The levels of sTREM-1, PCT, and 1,3--D glucan in the infection group after treatment were significantly lower than those before treatment ( < 0.05). The AUC value of sTREM-1 in the diagnosis of immune-related pulmonary diseases complicated with fungal infection was 0.980, the sensitivity was 97.11%, and the specificity was 83.06%. The AUC value of PCT in the diagnosis of immune-related pulmonary diseases complicated with fungal infection was 0.860, the sensitivity was 80.00%, and the specificity was 72.41%. The AUC value of 1,3--D glucan in the diagnosis of immune-related pulmonary diseases complicated with fungal infection was 0.993, the sensitivity was 98.74%, and the specificity was 99.16%. The levels of sTREM-1, PCT, and 1,3--D glucan in the infection group after treatment were considerably lower than those before treatment, and the difference was statistically significant ( < 0.05).

CONCLUSION

The detection of sTREM-1, PCT, and 1,3--D glucan levels has high clinical value for the diagnosis of immune-related pulmonary diseases complicated with fungal infection.

摘要

背景

肺部真菌感染可引起真菌性传染病。该疾病发展迅速，涉及范围广泛。致病真菌也是更严重类型的致病菌。如果它侵犯深部器官和组织，将危及生命，因此需要及时诊断。

目的

探讨血清可溶性髓系细胞触发受体-1（sTREM-1）、降钙素原（PCT）和 1,3-β-D 葡聚糖检测在免疫相关肺部疾病合并真菌感染中的诊断价值。

方法

本研究采用病例对照研究，选取 2017 年 1 月至 2021 年 12 月我院经痰培养诊断为免疫相关肺部疾病合并真菌感染的 50 例患者（感染组）为病例组，选取同期免疫相关肺部疾病无真菌感染的 50 例患者为对照组。比较两组患者 sTREM-1、PCT、1,3-β-D 葡聚糖水平，采用受试者工作特征（ROC）曲线分析 3 项指标对免疫相关肺部疾病合并真菌感染的诊断价值，并比较治疗前后 3 项指标的变化。

结果

感染组 sTREM-1、PCT、1,3-β-D 葡聚糖水平均高于对照组（ < 0.05）。感染组治疗后 sTREM-1、PCT、1,3-β-D 葡聚糖水平均明显低于治疗前（ < 0.05）。sTREM-1 诊断免疫相关肺部疾病合并真菌感染的 AUC 值为 0.980，灵敏度为 97.11%，特异度为 83.06%。PCT 诊断免疫相关肺部疾病合并真菌感染的 AUC 值为 0.860，灵敏度为 80.00%，特异度为 72.41%。1,3-β-D 葡聚糖诊断免疫相关肺部疾病合并真菌感染的 AUC 值为 0.993，灵敏度为 98.74%，特异度为 99.16%。感染组治疗后 sTREM-1、PCT、1,3-β-D 葡聚糖水平明显低于治疗前，差异有统计学意义（ < 0.05）。