Lin Yujun, Zhang Ge, Wang Yan, Chai Jianjun, Jiang Xiufang, Li Cong, Xu Hui
Department of Electrophysiology, Yantaishan Hospital of Yantai, Yantai, Shandong 264000, P.R. China.
Department of Obstetrics, People's Hospital of Zhangqiu, Jinan, Shandong 250200, P.R. China.
Exp Ther Med. 2018 Dec;16(6):5243-5247. doi: 10.3892/etm.2018.6882. Epub 2018 Oct 19.
This study investigated prognostic evaluation of child patients with viral encephalitis through ambulatory electroencephalogram (AEEG) and regular electroencephalogram (REEG). A total of 94 child patients who were clinically diagnosed with viral encephalitis in Yantaishan Hospital of Yantai from May 2010 to July 2014, was examined with AEEG and REEG, respectively and randomly divided into AEEG group (n=47) and REEG group (n=47). The probabilities of detecting abnormal electroencephalographic activities with two examination methods were compared. The detection rates of abnormal electroencephalographic activities with AEEG and REEG were 80.0 and 65.0%, respectively, with significant differences (P<0.05); the probabilities of detecting epileptiform discharge with AEEG and REEG were 42.5 and 6.3%, respectively, with significant differences (P<0.05). The hospitalization time and time of electroencephalogram (EEG) restoring to normal of child patients with encephalitis in the REEG group were significantly longer than those of child patients with encephalitis in the AEEG group, with statistically significant differences (P<0.05). Among child patients in the AEEG group, the incidence rate of severe illness was 2.1%, and both the incidence rates of clinical recurrence and of sequela were 0. Among child patients in the REEG group, the incidence rate, clinical recurrence rate and incidence rate of sequela were 8.5, 12.7 and 8.5%, respectively, with statistically significant differences (P<0.05). To some extent, the EEG abnormality reflects the disorder degree of brain environment of child patients with viral encephalitis. The treatment effect and prognosis of child patients with viral encephalitis can be clinically evaluated based on EEG monitoring results of child patients, which has a certain clinical guiding significance. AEEG has important significance to the auxiliary diagnosis of viral encephalitis, with higher sensitivity than REEG.
本研究通过动态脑电图(AEEG)和常规脑电图(REEG)对病毒性脑炎患儿进行预后评估。选取2010年5月至2014年7月在烟台毓璜顶医院临床诊断为病毒性脑炎的94例患儿,分别进行AEEG和REEG检查,并随机分为AEEG组(n = 47)和REEG组(n = 47)。比较两种检查方法检测异常脑电活动的概率。AEEG和REEG检测异常脑电活动的率分别为80.0%和65.0%,差异有统计学意义(P<0.05);AEEG和REEG检测癫痫样放电的概率分别为42.5%和6.3%,差异有统计学意义(P<0.05)。REEG组脑炎患儿的住院时间和脑电图恢复正常的时间显著长于AEEG组脑炎患儿,差异有统计学意义(P<0.05)。AEEG组患儿中,重症发病率为2.1%,临床复发率和后遗症发生率均为0。REEG组患儿中,发病率、临床复发率和后遗症发生率分别为8.5%、12.7%和8.5%,差异有统计学意义(P<0.05)。脑电图异常在一定程度上反映了病毒性脑炎患儿脑内环境的紊乱程度。根据患儿脑电图监测结果可对病毒性脑炎患儿的治疗效果及预后进行临床评估,具有一定的临床指导意义。AEEG对病毒性脑炎的辅助诊断具有重要意义,其敏感性高于REEG。