中风中的脂质运载蛋白-2
Lipocalin-2 in Stroke.
作者信息
Chou Wen-Hai, Wang Guona, Kumar Varun, Weng Yi-Chinn
机构信息
Department of Biological Sciences, School of Biomedical Sciences, Kent State University, Kent, OH 44224, USA.
出版信息
Neuro. 2015 Aug;2(1):38-41. doi: 10.17140/NOJ-2-109. Epub 2015 Apr 17.
Abstract
Stroke is a leading cause of adult disability in the United States. However, limited number of molecularly targeted therapy exists for stroke. Recent studies have shown that Li-pocalin-2 (LCN2) is an acute phase protein mediating neuroinflammation after ischemic and hemorrhagic strokes. This review is an attempt to summarize some LCN2-related research findings and discuss its role in stroke.
摘要
中风是美国成年人残疾的主要原因。然而，针对中风的分子靶向治疗数量有限。最近的研究表明，脂质运载蛋白2（LCN2）是一种急性期蛋白，在缺血性和出血性中风后介导神经炎症。这篇综述试图总结一些与LCN2相关的研究结果，并讨论其在中风中的作用。
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本文引用的文献
1
Identification of lipocalin-2 as a PKCδ phosphorylation substrate in neutrophils.
J Biomed Sci. 2015 Mar 20;22(1):21. doi: 10.1186/s12929-015-0129-z.
2
Lipocalin-2 released in response to cerebral ischaemia mediates reperfusion injury in mice.
J Cell Mol Med. 2015 Jul;19(7):1637-45. doi: 10.1111/jcmm.12538. Epub 2015 Feb 20.
3
Lipocalin-2 enhances angiogenesis in rat brain endothelial cells via reactive oxygen species and iron-dependent mechanisms.
J Neurochem. 2015 Mar;132(6):622-8. doi: 10.1111/jnc.13023. Epub 2015 Jan 29.
4
Heart disease and stroke statistics--2015 update: a report from the American Heart Association.
Circulation. 2015 Jan 27;131(4):e29-322. doi: 10.1161/CIR.0000000000000152. Epub 2014 Dec 17.
5
Generation and characterization of ATP analog-specific protein kinase Cδ.
J Biol Chem. 2015 Jan 23;290(4):1936-51. doi: 10.1074/jbc.M114.598698. Epub 2014 Dec 10.
6
Neuronal production of lipocalin-2 as a help-me signal for glial activation.
Stroke. 2014 Jul;45(7):2085-92. doi: 10.1161/STROKEAHA.114.005733. Epub 2014 Jun 10.
7
Acute white matter injury after experimental subarachnoid hemorrhage: potential role of lipocalin 2.
Stroke. 2014 Jul;45(7):2141-3. doi: 10.1161/STROKEAHA.114.005307. Epub 2014 Jun 3.
8
Lipocalin-2 deficiency attenuates neuroinflammation and brain injury after transient middle cerebral artery occlusion in mice.
J Cereb Blood Flow Metab. 2014 Aug;34(8):1306-14. doi: 10.1038/jcbfm.2014.83. Epub 2014 Apr 30.
9
Intracerebral hemorrhage: clinical overview and pathophysiologic concepts.
Transl Stroke Res. 2012 Jul;3(Suppl 1):10-24. doi: 10.1007/s12975-012-0175-8. Epub 2012 Apr 21.
10
Reactive astrocytes secrete lcn2 to promote neuron death.
Proc Natl Acad Sci U S A. 2013 Mar 5;110(10):4069-74. doi: 10.1073/pnas.1218497110. Epub 2013 Feb 19.
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