A Microscale Planar Linear Ion Trap Mass Spectrometer.

The planar linear ion trap (PLIT) is a version of the two-dimensional linear quadrupole ion trap constructed using two facing dielectric substrates on which electrodes are lithographically patterned. In this article, we present a PLIT that was successfully miniaturized from a radius of 2.5 mm to a microscale radius of 800 μm (a scaling factor of 3.125). The mathematics concerning scaling an ion trap mass spectrometer are demonstrated-including the tradeoff between RF power and pseudopotential well depth. The time average power for the microscale PLIT is, at best, ~ 1/100 that of the PLIT but at a cost of potential well depth of ~ 1/10 the original. Experimental data using toluene/deuterated toluene and isobutylbenze to verify trap performance demonstrated resolutions around 1.5 Da at a pressure of 5.4 × 10 Torr. The microscale PLIT was shown to retain resolutions between 2.3 and 2.7 Da at pressures up to 42 × 10 Torr while consuming a factor of 3.38 less time average power than the unscaled PLIT. Graphical Abstract.