在小型化平面线性离子阱质谱仪中使用新型射频相位跟踪电路的双共振喷射。
Double resonance ejection using novel radiofrequency phase tracking circuitry in a miniaturized planar linear ion trap mass spectrometer.
作者信息
Decker Trevor K, Zheng Yajun, McClellan Joshua S, Ruben Aaron J, Lammert Stephen A, Austin Daniel E, Hawkins Aaron R
机构信息
Electrical and Computer Engineering Department, Brigham Young University, Provo, UT, 84602-0002, USA.
Chemistry and Biochemistry Department, Brigham Young University, Provo, UT, 84602-0002, USA.
出版信息
Rapid Commun Mass Spectrom. 2018 Dec 15;32(23):2024-2030. doi: 10.1002/rcm.8267.
RATIONALE
Ion trap mass spectrometers are attractive due to their inherent sensitivity and specificity. Miniaturization increases trap portability for in situ mass analysis by relaxing vacuum and voltage requirements but decreases the trapping volume. To overcome signal/resolution loss from miniaturization, double resonance ejection using phase tracking circuitry was investigated.
METHODS
Phase tracking circuitry was developed to induce double resonance ejection in a planar linear ion trap using the β 2/3 hexapole resonance line.
RESULTS
Double resonance was observed using phase tracking circuitry. Resolution of 0.5 m/z units and improved signal-to-noise ratio (SNR) compared with AC resonant ejection were achieved.
CONCLUSIONS
The phase tracking circuitry proved effective despite deviations from a true phase locked condition. Double resonance ejection is a means to increase signal intensity in a miniaturized planar ion trap.
原理
离子阱质谱仪因其固有的灵敏度和特异性而具有吸引力。小型化通过放宽真空和电压要求提高了阱的便携性，便于进行原位质量分析，但会减小捕获体积。为了克服小型化导致的信号/分辨率损失，研究了使用相位跟踪电路的双共振喷射。
方法
开发了相位跟踪电路，以利用β 2/3六极共振线在平面线性离子阱中诱导双共振喷射。
结果
使用相位跟踪电路观察到了双共振。与交流共振喷射相比，实现了0.5 m/z单位的分辨率和改善的信噪比（SNR）。
结论
尽管偏离了真正的锁相条件，但相位跟踪电路证明是有效的。双共振喷射是一种增加小型化平面离子阱中信号强度的方法。
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