基于脂质-碳酸钙/磷酸盐纳米粒子的靶向递药平台增强癌症联合治疗
Enhanced combination cancer therapy using lipid-calcium carbonate/phosphate nanoparticles as a targeted delivery platform.
机构信息
Australian Institute for Bioengineering & Nanotechnology, The University of Queensland, St Lucia, QLD 4072, Australia.
出版信息
Nanomedicine (Lond). 2019 Jan;14(1):77-92. doi: 10.2217/nnm-2018-0252. Epub 2018 Dec 13.
AIM
Melanoma, the most life-threatening skin cancer, requires more effective therapies.
METHODOLOGY
A new folic acid (FA) receptor-targeted lipid-coated calcium carbonate/phosphate (LCCP) nanoparticle was synthesized, incorporating two often-used therapeutics, cell death siRNA and α-tocopheryl succinate.
RESULTS
The nanoparticles were spherical, with an average size of 40 nm. The nanoparticles exhibited a high gene/drug loading efficiency (60%), with folic acid-enhanced cellular uptake. The nanoparticles with both therapeutics enhanced inhibition of B16F0 melanoma cell growth, showing a moderate synergistic effect. The mechanism of the inhibition is associated with induction of cell apoptosis and cell cycle arrest at G1 phase.
CONCLUSION
Our data indicate that lipid-coated calcium carbonate/phosphate nanoparticles are a potential platform for targeted therapy for melanoma.
目的
黑色素瘤是最具致命性的皮肤癌，需要更有效的治疗方法。
方法
合成了一种新型叶酸（FA）受体靶向脂质包覆碳酸钙/磷酸盐（LCCP）纳米粒子，其中包含两种常用的治疗药物，细胞死亡 siRNA 和 α-生育酚琥珀酸酯。
结果
纳米粒子呈球形，平均粒径为 40nm。纳米粒子表现出高的基因/药物负载效率（60%），并具有叶酸增强的细胞摄取。同时含有两种治疗药物的纳米粒子增强了对 B16F0 黑色素瘤细胞生长的抑制作用，显示出适度的协同作用。抑制的机制与诱导细胞凋亡和 G1 期细胞周期停滞有关。
结论
我们的数据表明，脂质包覆碳酸钙/磷酸盐纳米粒子是黑色素瘤靶向治疗的一种有潜力的平台。
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