Hikami Kensuke, Ueda Masakatsu, Shibasaki Noboru, Yasui Hiroshi, Akao Toshiya
The Department of Urology, Rakuwakai Otowa Hospital.
The Department of Diagnostic Pathology, Rakuwakai Otowa Hospital.
Hinyokika Kiyo. 2018 Nov;64(11):439-443. doi: 10.14989/ActaUrolJap_64_11_439.
A 71-year-old man with left flank pain was referred to our hospital. Computed tomography (CT) revealed a left renal tumor, left renal pelvic wall thickening, bilateral adrenal gland swelling, multiple pulmonary nodules, and a bone metastatic tumor. Further, positron emission tomography/CT revealed increased 18F fluorodeoxyglucose uptake in the left renal tumor, multiple pulmonary nodules, and bone metastatic tumor. Accordingly, we performed biopsies of the thickening of the left renal pelvic wall and bone metastatic tumor, and histological examinations revealed an unknown type carcinoma and bone metastasis from clear cell carcinoma. Without a precise preoperative diagnosis of the thickening of the left renal pelvic wall, laparoscopic left nephrectomy was performed, and the renal and renal pelvic wall tumors were diagnosed as clear cell carcinoma on pathological examination. Therefore, we made a final diagnosis of renal cell carcinoma with lung, bone, and renal pelvic metastases. Although axitinib was administered, cervical spine metastasis developed. Unfortunately, the patient died from disease progression five months following the surgery.
一名71岁左侧腰痛男性被转诊至我院。计算机断层扫描(CT)显示左肾肿瘤、左肾盂壁增厚、双侧肾上腺肿大、多发肺结节及骨转移瘤。此外,正电子发射断层扫描/CT显示左肾肿瘤、多发肺结节及骨转移瘤处18F氟脱氧葡萄糖摄取增加。因此,我们对左肾盂壁增厚处及骨转移瘤进行了活检,组织学检查显示为不明类型癌及透明细胞癌骨转移。在未对左肾盂壁增厚进行精确术前诊断的情况下,实施了腹腔镜左肾切除术,术后病理检查显示肾及肾盂壁肿瘤为透明细胞癌。因此,我们最终诊断为肾细胞癌伴肺、骨及肾盂转移。尽管给予了阿昔替尼治疗,但仍发生了颈椎转移。不幸的是,患者术后5个月因疾病进展死亡。