逆转录病毒的 TRIM5α 限制：在笼中战斗的 RING 侧。
Retrovirus Restriction by TRIM5α: RINGside at a Cage Fight.
机构信息
Department of Biochemistry, University of Utah, Salt Lake City, UT, USA.
Department of Molecular Physiology and Biological Physics, University of Virginia, Charlottesville, VA, USA.
出版信息
Cell Host Microbe. 2018 Dec 12;24(6):751-753. doi: 10.1016/j.chom.2018.11.013.
Abstract
The restriction factor TRIM5α recognizes incoming retroviral capsids and blocks virus replication. In this issue of Cell Host & Microbe, Fletcher et al. (2018) show how the TRIM5α RING domain mediates formation of various ubiquitin conjugates that differentially regulate TRIM5α turnover, inhibition of viral reverse transcription, and innate immune activation.
摘要
限制因子 TRIM5α 识别进入的逆转录病毒衣壳并阻止病毒复制。在本期《Cell Host & Microbe》中，Fletcher 等人（2018）展示了 TRIM5α 的 RING 结构域如何介导各种泛素缀合物的形成，这些泛素缀合物差异调节 TRIM5α 的周转、抑制病毒逆转录和先天免疫激活。
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