Dipartimento di Scienze Cognitive, Psicologiche, Pedagogiche e degli studi culturali, Università di Messina, Messina, Italy; Dept. Psychology and Neurosciences, Leibniz Research Centre for Working Environment and Human Factors, Dortmund, Germany; School of Psychology, University of Tasmania, Hobart, TAS, Australia.
Dept. Psychology and Neurosciences, Leibniz Research Centre for Working Environment and Human Factors, Dortmund, Germany; International Graduate School of Neuroscience, Ruhr University Bochum, Bochum, Germany.
Neurosci Biobehav Rev. 2019 Jan;96:219-231. doi: 10.1016/j.neubiorev.2018.12.012. Epub 2018 Dec 10.
The interest in the use of non-invasive brain stimulation for enhancing neural functions and reducing symptoms in anxiety disorders is growing. Based on the DSM-V classification for anxiety disorders, we examined all available research using repetitive transcranial magnetic stimulation (rTMS) and transcranial direct current stimulation (tDCS) for the treatment of specific phobias, social anxiety disorder, panic disorder, agoraphobia, and generalized anxiety disorder. A systematic literature search conducted in PubMed and Google Scholar databases provided 26 results: 12 sham-controlled studies and 15 not sham-controlled studies. With regard to the latter sub-group of studies, 9 were case reports, and 6 open label studies. Overall, our work provides preliminary evidence that both, excitatory stimulation of the left prefrontal cortex and inhibitory stimulation of the right prefrontal cortex can reduce symptom severity in anxiety disorders. The current results are discussed in the light of a model for the treatment for anxiety disorders via non-invasive brain stimulation, which is based on up-/downregulation mechanisms and might serve as guide for future systematic investigations in the field.
人们对非侵入性脑刺激在增强神经功能和减轻焦虑障碍症状方面的应用越来越感兴趣。基于DSM-V 对焦虑障碍的分类,我们对所有使用重复经颅磁刺激(rTMS)和经颅直流电刺激(tDCS)治疗特定恐惧症、社交焦虑障碍、惊恐障碍、广场恐怖症和广泛性焦虑障碍的现有研究进行了检查。在 PubMed 和 Google Scholar 数据库中进行的系统文献检索提供了 26 项结果:12 项假刺激对照研究和 15 项非假刺激对照研究。关于后者的亚组研究,有 9 项是病例报告,6 项是开放标签研究。总的来说,我们的工作初步证明,左前额叶的兴奋刺激和右前额叶的抑制刺激都可以减轻焦虑障碍的症状严重程度。目前的结果是在基于上调/下调机制的焦虑障碍非侵入性脑刺激治疗模型的基础上讨论的,该模型可能为该领域未来的系统研究提供指导。
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