Sackler Centre for Consciousness Science, University of Sussex, University Kingdom; Department of Neuroscience, Brighton & Sussex Medical School, United Kingdom.
Sackler Centre for Consciousness Science, University of Sussex, University Kingdom; Department of Neuroscience, Brighton & Sussex Medical School, United Kingdom.
Psychiatry Res. 2019 Jan;271:469-475. doi: 10.1016/j.psychres.2018.12.036. Epub 2018 Dec 6.
Interoceptive processes in Tourette syndrome may foster the premonitory urges that commonly precede tics. Twenty-one adults with TS and 22 controls completed heartbeat tracking and discrimination tasks. Three dimensions of interoception were examined: objective accuracy, metacognitive awareness, and subjective (self-report) sensibility. Trait interoceptive prediction error was calculated as the discrepancy between accuracy and sensibility. Participants with TS had numerically lower interoceptive accuracy on the heartbeat tracking task, and increased self-reported interoceptive sensibility. While these group differences were not significant, the discrepancy between lower interoceptive accuracy and heightened sensibility, i.e. the trait interoceptive prediction error, was significantly greater in TS compared to controls. This suggests a heightened higher-order sensitivity to bodily sensations in TS, relative to a noisier perceptual representation of afferent bodily signals. Moreover, interoceptive sensibility predicted the severity of premonitory sensations and tics. This suggests interventions that work to align dimensions of interoceptive experience in TS hold therapeutic potential.
抽动秽语综合征中的内感受过程可能会促进通常先于抽动出现的预感冲动。21 名抽动秽语综合征患者和 22 名对照者完成了心跳跟踪和辨别任务。检查了内感受的三个维度：客观准确性、元认知意识和主观（自我报告）敏感性。特质内感受预测误差被计算为准确性和敏感性之间的差异。在心跳跟踪任务中，抽动秽语综合征患者的内感受准确性数值较低，自我报告的内感受敏感性增加。虽然这些组间差异并不显著，但在抽动秽语综合征患者中，较低的内感受准确性和更高的敏感性之间的差异，即特质内感受预测误差，明显大于对照组。这表明，与传入身体信号的嘈杂感知表示相比，抽动秽语综合征患者对身体感觉的高阶敏感性增强。此外，内感受敏感性预测了预感感觉和抽动的严重程度。这表明，针对抽动秽语综合征患者的内感受体验的干预措施具有治疗潜力。
