Sobell Department of Motor Neuroscience and Movement Disorders, UCL Institute of Neurology, University College London, London, UK.
Department of Neurology, University Medical Center Hamburg-Eppendorf (UKE), Hamburg, Germany.
Mov Disord. 2015 Aug;30(9):1198-202. doi: 10.1002/mds.26228. Epub 2015 Apr 16.
A contribution of aberrant interoceptive awareness to the perception of premonitory urges in Gilles de la Tourette syndrome (GTS) has been hypothesized.
We assessed interoceptive awareness in 19 adults with GTS and 25 age-matched healthy controls using the heartbeat counting task. We also used multiple regression to explore whether the severity of premonitory urges was predicted by interoceptive awareness or severity of tics and obsessive-compulsive symptoms.
We observed lower interoceptive awareness in GTS compared with controls. Interoceptive awareness was the strongest predictor of premonitory urges in GTS, with greater interoceptive awareness being associated with more urges. Greater tic severity was also associated with higher rates of premonitory urges.
The observed relationship between severity of premonitory urges and interoceptive awareness suggests that interoception might be involved in self-reported premonitory urges in GTS. High levels of interoceptive awareness might reflect a self-attentive capacity to perceive urges.
人们假设，异常的内脏感知觉可能会导致 Gilles de la Tourette 综合征（GTS）患者出现预感冲动的感知。
我们使用心跳计数任务评估了 19 名 GTS 成年患者和 25 名年龄匹配的健康对照者的内脏感知觉。我们还使用多元回归分析来探索内脏感知觉的严重程度、抽搐和强迫症状的严重程度是否可以预测预感冲动的严重程度。
与对照组相比，GTS 患者的内脏感知觉较低。内脏感知觉是 GTS 预感冲动的最强预测因子，内脏感知觉越差，预感冲动越多。抽搐的严重程度也与更高的预感冲动发生率相关。
观察到预感冲动的严重程度与内脏感知觉之间的关系表明，内脏感知觉可能与 GTS 患者自述的预感冲动有关。较高的内脏感知觉水平可能反映了一种自我注意的能力，能够感知冲动。
