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主动脉手术后胸骨切开术后深部伤口感染:预防假体移植物置换的伤口护理策略†。

Post-sternotomy deep wound infection following aortic surgery: wound care strategies to prevent prosthetic graft replacement†.

机构信息

Department of Cardiovascular Surgery, Kobe University Graduate School of Medicine, Kobe, Japan.

Department of Plastic Surgery, Kobe University Graduate School of Medicine, Kobe, Japan.

出版信息

Eur J Cardiothorac Surg. 2019 May 1;55(5):975-983. doi: 10.1093/ejcts/ezy389.

Abstract

OBJECTIVES

The aim of this study was to evaluate the early and long-term outcomes of our multidisciplinary strategy for treating deep sternal wound infection after aortic grafting, which consisted of debridement by a plastic surgeon, negative pressure wound therapy with continuous irrigation and chest wall reconstruction.

METHODS

We performed a retrospective analysis of 18 patients who had a deep sternal wound infection following aortic grafting through a median sternotomy between January 2009 and December 2017. All patients had organisms cultured from mediastinal tissue within 2 months from the initial aortic surgery. The prosthetic grafts were exposed in 15 patients during resternotomy. Our protocol involved repeat debridement and negative pressure wound therapy with continuous irrigation twice a week until the results of the culture were negative and chest wall reconstruction was complete.

RESULTS

The mean duration from primary aortic surgery to resternotomy was 23.7 ± 15.9 days. Except for 1 patient, 17 patients underwent chest wall reconstruction. The mean duration from resternotomy to chest wall reconstruction was 31.1 ± 28.0 days. The hospital mortality rate was 16.7% (3 patients), although no patients died of wound-related causes. The mean follow-up period was 2.9 ± 2.5 years. Overall survival was 69.6 ± 11.4% at 1 year and 54.2 ± 13.3% at 5 years. Freedom from reoperation for reinfection was 94.4 ± 5.4% at 5 years.

CONCLUSIONS

Our wound care strategy achieved acceptable early and late survival in patients who had deep sternal wound infection following aortic grafting. This strategy may benefit those who experience this devastating complication.

摘要

目的

本研究旨在评估我们治疗主动脉移植术后深部胸骨伤口感染的多学科策略的早期和长期结果,该策略包括整形外科医生清创、负压伤口治疗持续灌洗和胸壁重建。

方法

我们对 2009 年 1 月至 2017 年 12 月期间通过正中胸骨切开术行主动脉移植术后发生深部胸骨伤口感染的 18 例患者进行回顾性分析。所有患者在初次主动脉手术后 2 个月内均从纵隔组织中培养出病原体。15 例患者在再次开胸时暴露了假体移植物。我们的方案包括重复清创和每周两次的负压伤口治疗持续灌洗,直到培养结果为阴性且胸壁重建完成。

结果

从初次主动脉手术到再次开胸的平均时间为 23.7±15.9 天。除 1 例患者外,17 例患者均进行了胸壁重建。再次开胸到胸壁重建的平均时间为 31.1±28.0 天。住院死亡率为 16.7%(3 例),但无患者因伤口相关原因死亡。平均随访时间为 2.9±2.5 年。1 年时总生存率为 69.6±11.4%,5 年时为 54.2±13.3%。5 年时再次感染的无再手术率为 94.4±5.4%。

结论

我们的伤口护理策略在主动脉移植术后发生深部胸骨伤口感染的患者中取得了可接受的早期和晚期生存率。该策略可能有益于那些经历这种破坏性并发症的患者。

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