Inoue-Murayama Miho, Niimi Youko, Takenaka Osamu, Okada Kyoko, Matsuzaki Ichiyo, Ito Shin'ichi, Murayama Yuichi
Department of Biological Diversity and Resources, Faculty of Agriculture, Gifu University, Gifu, Japan.
Primate Research Institute, Kyoto University, Inuyama, Aichi, Japan.
Primates. 2000 Jul;41(3):267-273. doi: 10.1007/BF02557596.
To assess the change of serotonin transporter (5-HTT) gene-linked polymorphic region that has occurred during the process of hominization, we examined the allelic variation of 5-HTT gene-linked polymorphic region (5-HTTLPR) in anthropoid apes such as chimpanzees, gorillas, orang-utans, and gibbons, and determined the DNA sequences of the alleles in each species. All chimpanzees examined shared only the 17.5 repeat allele, while polymorphism was observed in the other apes and the 16 and 20 repeat alleles were most frequent in gorillas and orang-utans, respectively. 5-HTTLPR was highly polymorphic in gibbons and the 17 and 23 repeat alleles were most common among 5 alleles. Alleles with extra-long repeated (22 and 23) sequences were found in orang-utans and gibbons, and the alleles of these Asian apes were similar to the rhesus monkey allele.
为了评估在人类进化过程中发生的血清素转运体（5-HTT）基因连锁多态性区域的变化，我们检测了黑猩猩、大猩猩、猩猩和长臂猿等类人猿中5-HTT基因连锁多态性区域（5-HTTLPR）的等位基因变异，并确定了每个物种中等位基因的DNA序列。所有检测的黑猩猩仅共享17.5重复等位基因，而在其他猿类中观察到多态性，16和20重复等位基因分别在大猩猩和猩猩中最为常见。5-HTTLPR在长臂猿中高度多态，17和23重复等位基因在5个等位基因中最为常见。在猩猩和长臂猿中发现了具有超长重复（22和23）序列的等位基因，这些亚洲猿类的等位基因与恒河猴等位基因相似。
