Zuo Hong, Zhang Ying, Ma Qiaojuan
Department of Cardiovascular Medicine, Xianyang Central Hospital, Xianyang, Shaanxi 712000, P.R. China.
Department of Nephrology, Hanzhong Central Hospital, Hanzhong, Shaanxi 723000, P.R. China.
Exp Ther Med. 2018 Dec;16(6):4669-4673. doi: 10.3892/etm.2018.6801. Epub 2018 Sep 27.
Correlation between coronary atherosclerosis calcification and epicardial adipose tissue (EAT) volume in patients with nephropathy was investigated. A total of 529 patients with high risk of coronary atherosclerotic nephropathy were selected from August 2013 to September 2016 in Xianyang Central Hospital to serve as research subjects, and their clinical data were retrospectively analyzed. All patients underwent coronary artery and EAT examination using dual-source CT. Correlation between EAT and severity of coronary atherosclerosis, calcification, lesions, and BMI were analyzed. Volume of EAT in patients with atherosclerosis was significantly higher than that in patients without atherosclerosis (p<0.05). EAT volume was positively correlated with BMI (r=0.61, p<0.05), calcification scores (r=0.72, p<0.05) and the number of coronary artery lesions (r=0.64, p<0.05) in patients with nephropathy. Coronary atherosclerosis calcification score, number of lesions and BMI are positively correlated with the EAT volume in patients with nephropathy. Detection of EAT volume may serve as a predictor of the occurrence and develop-ment of coronary atherosclerosis in the future.
研究了肾病患者冠状动脉粥样硬化钙化与心外膜脂肪组织(EAT)体积之间的相关性。2013年8月至2016年9月,从咸阳市中心医院选取529例冠状动脉粥样硬化性肾病高危患者作为研究对象,对其临床资料进行回顾性分析。所有患者均采用双源CT进行冠状动脉和EAT检查。分析了EAT与冠状动脉粥样硬化严重程度、钙化、病变及BMI之间的相关性。动脉粥样硬化患者的EAT体积显著高于无动脉粥样硬化患者(p<0.05)。肾病患者的EAT体积与BMI(r=0.61,p<0.05)、钙化评分(r=0.72,p<0.05)及冠状动脉病变数量(r=0.64,p<0.05)呈正相关。肾病患者的冠状动脉粥样硬化钙化评分、病变数量及BMI与EAT体积呈正相关。检测EAT体积可能作为未来冠状动脉粥样硬化发生和发展的预测指标。