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Diabetes Research Group, Life Sciences Institute, Department of Cellular and Physiological Sciences, University of British Columbia, Vancouver, Canada.

出版信息

Elife. 2018 Dec 14;7:e43475. doi: 10.7554/eLife.43475.

DOI:10.7554/eLife.43475

PMID:30547883

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6294546/

Abstract

Exploring how proliferation and maturation of beta-cells can be impaired after birth will shed light on the origins of various forms of diabetes.

摘要

探讨出生后β细胞的增殖和成熟如何受损，将有助于了解各种形式糖尿病的发病机制。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dc3c/6294546/dd7f6b05e251/elife-43475-fig1.jpg

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Folding mutations suppress early beta-cell proliferation.折叠突变抑制早期β细胞增殖。

Elife. 2018 Dec 14;7:e43475. doi: 10.7554/eLife.43475.

2

Insulin mutations impair beta-cell development in a patient-derived iPSC model of neonatal diabetes.胰岛素突变损害了新生儿糖尿病患者来源的 iPSC 模型中的β细胞发育。

Elife. 2018 Nov 9;7:e38519. doi: 10.7554/eLife.38519.

3

INS-gene mutations: from genetics and beta cell biology to clinical disease.胰岛素基因（INS）突变：从遗传学和β细胞生物学到临床疾病

Mol Aspects Med. 2015 Apr;42:3-18. doi: 10.1016/j.mam.2014.12.001. Epub 2014 Dec 24.

4

Mice conditionally lacking the Wolfram gene in pancreatic islet beta cells exhibit diabetes as a result of enhanced endoplasmic reticulum stress and apoptosis.在胰岛β细胞中条件性缺乏Wolfram基因的小鼠，由于内质网应激和细胞凋亡增强而表现出糖尿病。

Diabetologia. 2005 Nov;48(11):2313-21. doi: 10.1007/s00125-005-1947-4. Epub 2005 Oct 8.

5

Disulfide Mispairing During Proinsulin Folding in the Endoplasmic Reticulum.内质网中胰岛素原折叠过程中的二硫键错配

Diabetes. 2016 Apr;65(4):1050-60. doi: 10.2337/db15-1345. Epub 2016 Jan 28.

6

Permanent neonatal diabetes mellitus due to a C96Y heterozygous mutation in the insulin gene. A case report.胰岛素基因C96Y杂合突变导致的永久性新生儿糖尿病。病例报告。

JOP. 2008 Nov 3;9(6):715-8.

7

Na(+)/Ca (2+) exchange and the plasma membrane Ca(2+)-ATPase in β-cell function and diabetes.钠钙交换和质膜钙泵在β细胞功能和糖尿病中的作用。

Adv Exp Med Biol. 2013;961:385-94. doi: 10.1007/978-1-4614-4756-6_33.

8

The various phenotypes of diabetes and the endoplasmic reticulum of the beta cell.

Rom J Intern Med. 2007;45(3):287-91.

9

Lipotoxic endoplasmic reticulum stress, β cell failure, and type 2 diabetes mellitus.脂毒性内质网应激、β 细胞衰竭与 2 型糖尿病。

Trends Endocrinol Metab. 2014 Aug;25(8):389-98. doi: 10.1016/j.tem.2014.02.003. Epub 2014 Mar 18.

10

An update on lipotoxic endoplasmic reticulum stress in pancreatic beta-cells.胰腺β细胞中脂毒性内质网应激的最新进展。

Biochem Soc Trans. 2008 Oct;36(Pt 5):909-15. doi: 10.1042/BST0360909.

引用本文的文献

1

Exercise and inactivity as modifiers of β cell function and type 2 diabetes risk.运动和不运动对β细胞功能和 2 型糖尿病风险的影响。

J Appl Physiol (1985). 2023 Apr 1;134(4):823-839. doi: 10.1152/japplphysiol.00472.2022. Epub 2023 Feb 9.

2

Label-free proteomics analysis on the envelope of budded viruses of Bombyx mori nucleopolyhedrovirus harboring differential localized GP64.对携带差异定位的GP64的家蚕核型多角体病毒出芽病毒包膜进行无标记蛋白质组学分析。

Virus Genes. 2023 Apr;59(2):260-275. doi: 10.1007/s11262-022-01961-1. Epub 2022 Dec 13.

3

On the causal relationships between hyperinsulinaemia, insulin resistance, obesity and dysglycaemia in type 2 diabetes.

本文引用的文献

1

β Cell Replacement after Gene Editing of a Neonatal Diabetes-Causing Mutation at the Insulin Locus.经胰岛素基因座致新生儿糖尿病突变的基因编辑后β细胞的替代。

Stem Cell Reports. 2018 Dec 11;11(6):1407-1415. doi: 10.1016/j.stemcr.2018.11.006. Epub 2018 Nov 29.

2

Insulin mutations impair beta-cell development in a patient-derived iPSC model of neonatal diabetes.胰岛素突变损害了新生儿糖尿病患者来源的 iPSC 模型中的β细胞发育。

Elife. 2018 Nov 9;7:e38519. doi: 10.7554/eLife.38519.

3

Inhibition of mTORC1 by ER stress impairs neonatal β-cell expansion and predisposes to diabetes in the mouse.

折叠突变抑制早期β细胞增殖。

Folding mutations suppress early beta-cell proliferation.

机构信息

Diabetes Research Group, Life Sciences Institute, Department of Cellular and Physiological Sciences, University of British Columbia, Vancouver, Canada.

出版信息

Elife. 2018 Dec 14;7:e43475. doi: 10.7554/eLife.43475.

DOI:10.7554/eLife.43475

PMID:30547883

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6294546/

Abstract

Exploring how proliferation and maturation of beta-cells can be impaired after birth will shed light on the origins of various forms of diabetes.

摘要

探讨出生后β细胞的增殖和成熟如何受损，将有助于了解各种形式糖尿病的发病机制。

相似文献

1

Folding mutations suppress early beta-cell proliferation.折叠突变抑制早期β细胞增殖。

Elife. 2018 Dec 14;7:e43475. doi: 10.7554/eLife.43475.

2

Insulin mutations impair beta-cell development in a patient-derived iPSC model of neonatal diabetes.胰岛素突变损害了新生儿糖尿病患者来源的 iPSC 模型中的β细胞发育。

Elife. 2018 Nov 9;7:e38519. doi: 10.7554/eLife.38519.

3

INS-gene mutations: from genetics and beta cell biology to clinical disease.胰岛素基因（INS）突变：从遗传学和β细胞生物学到临床疾病

Mol Aspects Med. 2015 Apr;42:3-18. doi: 10.1016/j.mam.2014.12.001. Epub 2014 Dec 24.

4

Mice conditionally lacking the Wolfram gene in pancreatic islet beta cells exhibit diabetes as a result of enhanced endoplasmic reticulum stress and apoptosis.在胰岛β细胞中条件性缺乏Wolfram基因的小鼠，由于内质网应激和细胞凋亡增强而表现出糖尿病。

Diabetologia. 2005 Nov;48(11):2313-21. doi: 10.1007/s00125-005-1947-4. Epub 2005 Oct 8.

5

Disulfide Mispairing During Proinsulin Folding in the Endoplasmic Reticulum.内质网中胰岛素原折叠过程中的二硫键错配

Diabetes. 2016 Apr;65(4):1050-60. doi: 10.2337/db15-1345. Epub 2016 Jan 28.

6

Permanent neonatal diabetes mellitus due to a C96Y heterozygous mutation in the insulin gene. A case report.胰岛素基因C96Y杂合突变导致的永久性新生儿糖尿病。病例报告。

JOP. 2008 Nov 3;9(6):715-8.

7

Na(+)/Ca (2+) exchange and the plasma membrane Ca(2+)-ATPase in β-cell function and diabetes.钠钙交换和质膜钙泵在β细胞功能和糖尿病中的作用。

Adv Exp Med Biol. 2013;961:385-94. doi: 10.1007/978-1-4614-4756-6_33.

8

The various phenotypes of diabetes and the endoplasmic reticulum of the beta cell.

Rom J Intern Med. 2007;45(3):287-91.

9

Lipotoxic endoplasmic reticulum stress, β cell failure, and type 2 diabetes mellitus.脂毒性内质网应激、β 细胞衰竭与 2 型糖尿病。

Trends Endocrinol Metab. 2014 Aug;25(8):389-98. doi: 10.1016/j.tem.2014.02.003. Epub 2014 Mar 18.

10

An update on lipotoxic endoplasmic reticulum stress in pancreatic beta-cells.胰腺β细胞中脂毒性内质网应激的最新进展。

Biochem Soc Trans. 2008 Oct;36(Pt 5):909-15. doi: 10.1042/BST0360909.

引用本文的文献

1

Exercise and inactivity as modifiers of β cell function and type 2 diabetes risk.运动和不运动对β细胞功能和 2 型糖尿病风险的影响。

J Appl Physiol (1985). 2023 Apr 1;134(4):823-839. doi: 10.1152/japplphysiol.00472.2022. Epub 2023 Feb 9.

2

Label-free proteomics analysis on the envelope of budded viruses of Bombyx mori nucleopolyhedrovirus harboring differential localized GP64.对携带差异定位的GP64的家蚕核型多角体病毒出芽病毒包膜进行无标记蛋白质组学分析。

Virus Genes. 2023 Apr;59(2):260-275. doi: 10.1007/s11262-022-01961-1. Epub 2022 Dec 13.

3

On the causal relationships between hyperinsulinaemia, insulin resistance, obesity and dysglycaemia in type 2 diabetes.

本文引用的文献

1

β Cell Replacement after Gene Editing of a Neonatal Diabetes-Causing Mutation at the Insulin Locus.经胰岛素基因座致新生儿糖尿病突变的基因编辑后β细胞的替代。

Stem Cell Reports. 2018 Dec 11;11(6):1407-1415. doi: 10.1016/j.stemcr.2018.11.006. Epub 2018 Nov 29.

2

Insulin mutations impair beta-cell development in a patient-derived iPSC model of neonatal diabetes.胰岛素突变损害了新生儿糖尿病患者来源的 iPSC 模型中的β细胞发育。

Elife. 2018 Nov 9;7:e38519. doi: 10.7554/eLife.38519.

3

Inhibition of mTORC1 by ER stress impairs neonatal β-cell expansion and predisposes to diabetes in the mouse.

在 2 型糖尿病中，高胰岛素血症、胰岛素抵抗、肥胖和糖代谢紊乱之间的因果关系。

Diabetologia. 2021 Oct;64(10):2138-2146. doi: 10.1007/s00125-021-05505-4. Epub 2021 Jul 22.

4

Therapeutic opportunities for pancreatic β-cell ER stress in diabetes mellitus.糖尿病中胰岛β细胞内质网应激的治疗机会。

Nat Rev Endocrinol. 2021 Aug;17(8):455-467. doi: 10.1038/s41574-021-00510-4. Epub 2021 Jun 23.

5

The making of insulin in health and disease.胰岛素在健康和疾病中的作用。

Diabetologia. 2020 Oct;63(10):1981-1989. doi: 10.1007/s00125-020-05192-7. Epub 2020 Sep 7.

6

Misfolded proinsulin impairs processing of precursor of insulin receptor and insulin signaling in β cells.错误折叠的胰岛素原会损害β细胞中胰岛素受体前体和胰岛素信号的加工。

FASEB J. 2019 Oct;33(10):11338-11348. doi: 10.1096/fj.201900442R. Epub 2019 Aug 1.

内质网应激抑制 mTORC1 会损害新生β细胞的增殖，并使小鼠易患糖尿病。

Elife. 2018 Nov 9;7:e38472. doi: 10.7554/eLife.38472.

4

Pseudotime Ordering of Single Human β-Cells Reveals States of Insulin Production and Unfolded Protein Response.单细胞人β细胞的拟时排序揭示了胰岛素产生和未折叠蛋白反应的状态。

Diabetes. 2018 Sep;67(9):1783-1794. doi: 10.2337/db18-0365. Epub 2018 Jun 27.

5

Dynamics and Regulation of Insulin Secretion in Pancreatic Islets from Normal Young Children.正常幼儿胰岛中胰岛素分泌的动力学与调节

PLoS One. 2016 Nov 2;11(11):e0165961. doi: 10.1371/journal.pone.0165961. eCollection 2016.

6

The quest to make fully functional human pancreatic beta cells from embryonic stem cells: climbing a mountain in the clouds.从胚胎干细胞制造出功能完备的人类胰腺β细胞的探索：攀登云中高峰。

Diabetologia. 2016 Oct;59(10):2047-57. doi: 10.1007/s00125-016-4059-4. Epub 2016 Jul 29.

7

Reduced Insulin Production Relieves Endoplasmic Reticulum Stress and Induces β Cell Proliferation.胰岛素产生减少可缓解内质网应激并诱导β细胞增殖。

Cell Metab. 2016 Jan 12;23(1):179-93. doi: 10.1016/j.cmet.2015.10.016. Epub 2015 Nov 25.

8

The role of aging upon β cell turnover.衰老对β细胞更新的作用。

J Clin Invest. 2013 Mar;123(3):990-5. doi: 10.1172/JCI64095. Epub 2013 Mar 1.

9

Stimulation of autophagy improves endoplasmic reticulum stress-induced diabetes.自噬的刺激可改善内质网应激诱导的糖尿病。

Diabetes. 2013 Apr;62(4):1227-37. doi: 10.2337/db12-1474. Epub 2012 Dec 28.

10

Formation of a human β-cell population within pancreatic islets is set early in life.胰岛内的人β细胞群体的形成发生在生命早期。

J Clin Endocrinol Metab. 2012 Sep;97(9):3197-206. doi: 10.1210/jc.2012-1206. Epub 2012 Jun 28.

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Suppr 超能文献

文献检索

文件翻译

深度研究

折叠突变抑制早期β细胞增殖。

Folding mutations suppress early beta-cell proliferation.

机构信息

出版信息

相似文献

引用本文的文献

本文引用的文献

折叠突变抑制早期β细胞增殖。

Folding mutations suppress early beta-cell proliferation.

机构信息

出版信息

相似文献

引用本文的文献

本文引用的文献