Oncology Department, Tianjin Medical University General Hospital, Tianjin, China.
J Cell Physiol. 2019 Jul;234(7):10918-10925. doi: 10.1002/jcp.27917. Epub 2018 Dec 13.
In the US, lung carcinoma accounted for over 150,000 deaths in 2018 and the advances in increasing survival rates are still limited. In this study, we investigated the cohorts with lung adenocarcinoma (LUAD) or lung squamous cell carcinoma (LUSC) from The Cancer Genome Atlas to figure out the risk factors and genomic alterations that affected their prognosis. The histoclinical factors that differed between LUAD and LUSC were identified and the risk factors affecting the overall survival were figured out for both LUAD and LUSC. Next, the patterns of nucleotides substitutions and the mutational signatures were extracted to illustrate whether different mutational processes performed for them. Finally, the genes that had different frequencies of mutation were identified. LUAD and LUSC presented differences in histoclinical factors including age at the time of diagnosis, sex, smoking history, pathological T classification, and overall survival. This was caused by the distinct genomic alterations including the transition-to-transversion ratios, mutational signatures, and the frequently mutated genes. We proposed that the mutational signature associated with aging could be used to predict the prognosis of patients with LUAD. On the other hand, the AID/APOBEC family was associated with the prognosis of LUSC. Finally, SNTG1 and LRRK2 might be important in LUAD and LUSC, respectively.
在 2018 年，美国有超过 150000 人死于肺癌，而提高生存率的进展仍然有限。在这项研究中，我们从癌症基因组图谱（The Cancer Genome Atlas）调查了肺腺癌（LUAD）或肺鳞癌（LUSC）患者队列，以找出影响其预后的危险因素和基因组改变。确定了 LUAD 和 LUSC 之间在组织临床因素上的差异，并找出了影响 LUAD 和 LUSC 总生存率的危险因素。接下来，提取核苷酸取代模式和突变特征，以说明它们是否存在不同的突变过程。最后，确定了基因突变频率不同的基因。LUAD 和 LUSC 在组织临床因素方面存在差异，包括诊断时的年龄、性别、吸烟史、病理 T 分类和总生存率。这是由不同的基因组改变引起的，包括转换-颠换比、突变特征和经常发生突变的基因。我们提出，与衰老相关的突变特征可用于预测 LUAD 患者的预后。另一方面，AID/APOBEC 家族与 LUSC 的预后相关。最后，SNTG1 和 LRRK2 可能分别在 LUAD 和 LUSC 中很重要。
