通过模拟进行欺骗：一种细胞抗病毒策略。
Deception through Mimicry: A Cellular Antiviral Strategy.
机构信息
Department of Integrative Structural and Computational Biology, the Scripps Research Institute, La Jolla, CA 92037, USA.
Department of Integrative Structural and Computational Biology, the Scripps Research Institute, La Jolla, CA 92037, USA.
出版信息
Cell. 2018 Dec 13;175(7):1728-1729. doi: 10.1016/j.cell.2018.11.033.
Viruses use mimicry to hijack cellular machinery, but can human cells use mimicry as an antiviral approach? Batra et al. identify a novel antiviral restriction factor, RBBP6, by characterizing the cellular interactome of Ebola virus. RBBP6 targets the Ebola virus transcription factor VP30 by mimicking the binding of Ebola virus nucleoprotein.
病毒利用模拟作用劫持细胞机制，但人类细胞能否利用模拟作用作为一种抗病毒方法？Batra 等人通过描绘埃博拉病毒的细胞相互作用组，鉴定了一种新型抗病毒限制因子 RBBP6。RBBP6 通过模拟埃博拉病毒核蛋白的结合来靶向埃博拉病毒转录因子 VP30。
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