Vlietstra R E, Assad-Morell J L, Frye R L, Elveback L R, Connolly D C, Ritman E L, Pluth J R, Barnhorst D A, Danielson G K, Wallace R B
Mayo Clin Proc. 1977 Feb;52(2):85-90.
Linear discriminant function analysis was used to test the independent prognostic value of nine variables in patients with coronary artery diseaase. For 68 medically treated patients who met the criteria for inclusion in the discriminant function analysis, the most reliable predictor of 2-year survival status was the left ventricular ejection fraction. The prognostic value of the ejection fraction was not improved by the addition of the number of vessels diseased. Comparisons of the survival of 130 medical and 284 surgical patients were made using subsets based on the ejection fraction. When the ejection fraction was greater than or equal to 50%, the probability of 4-year survival was high for both medical (91%) and surgical (96%) groups. When the ejection fraction was less than 25%, the probability of 2-year survival was low in both groups. However, for patients with ejection fraction 25 through 49%, the surgical patients had a better chance (P less than 0.05) for a 3-year survival (89%) than did medical patients (68%). This study emphasizes the prognostic significance of the left ventricular ejection fraction, which should be considered in any comparison of survival in medically and surgically treated patients.
线性判别函数分析用于检验九个变量对冠心病患者的独立预后价值。对于68例符合判别函数分析纳入标准的接受药物治疗的患者，左心室射血分数是2年生存状态最可靠的预测指标。增加病变血管数量并不能提高射血分数的预后价值。基于射血分数对130例接受药物治疗的患者和284例接受手术治疗的患者的生存情况进行了亚组比较。当射血分数大于或等于50%时，药物治疗组（91%）和手术治疗组（96%）4年生存概率均较高。当射血分数小于25%时，两组2年生存概率均较低。然而，对于射血分数在25%至49%之间的患者，手术治疗患者3年生存概率（89%）高于药物治疗患者（68%），差异有统计学意义（P<0.05）。本研究强调了左心室射血分数的预后意义，在比较药物治疗和手术治疗患者的生存情况时应予以考虑。
