Department of Medicine, Universitat Jaume 1, Castellon, Spain.
Department of Biochemistry, Université Libre de Bruxelles, Brussels, Belgium.
Pflugers Arch. 2019 Apr;471(4):647-654. doi: 10.1007/s00424-018-2237-6. Epub 2018 Dec 14.
Over recent years, the presence of the sweet taste receptor TIR3 in rodent and human insulin-producing pancreatic islet β-cells was documented. The activation of this receptor by sweet-tasting sucralose mimics several biochemical and functional effects of D-glucose in the β-cells. The present study extends this analogy to the bioelectrical response of β-cells. In this respect, sucralose was inefficient in the absence of D-glucose, but induced on occasion electrical activity in mouse β-cells exposed to low non-stimulatory concentrations of the hexose and potentiated, in a concentration-related manner, the response to stimulatory concentrations of D-glucose. These data indicate that sucralose, acting as an agonist of the TIR3 receptor, exerts an excitatory effect upon pancreatic β-cell bioelectrical activity.
近年来,有研究证明,甜味受体 TIR3 存在于啮齿动物和人类产生胰岛素的胰腺胰岛 β 细胞中。该受体被甜味剂三氯蔗糖激活后,可模拟 D-葡萄糖对 β 细胞的多种生化和功能作用。本研究将这一类比扩展到了 β 细胞的生物电反应上。在这方面,当缺乏 D-葡萄糖时,三氯蔗糖的作用效率较低,但在暴露于低浓度非刺激性六碳糖的情况下,偶尔会诱导小鼠 β 细胞产生电活动,并以浓度相关的方式增强对刺激浓度 D-葡萄糖的反应。这些数据表明,三氯蔗糖作为 TIR3 受体的激动剂,对胰腺 β 细胞的生物电活动发挥兴奋作用。