Burns Unit, Concord Repatriation General Hospital, Sydney, Australia; ANZAC Research Institute, Concord Repatriation General Hospital, Sydney, Australia.
Burns Unit, Concord Repatriation General Hospital, Sydney, Australia; Sydney Medical School, University of Sydney, Sydney, Australia.
Burns. 2019 Jun;45(4):936-941. doi: 10.1016/j.burns.2018.11.013. Epub 2018 Dec 12.
Biobrane™ is a skin substitute used for the definitive management of partial thickness burns. No studies have examined the optimal timing of Biobrane™ application in this setting. The purpose of this study was to determine whether there was a clinically significant difference in applying Biobrane to a superficial and mid dermal partial thickness burn within 12h after burn.
From August 2016-February 2017, 29 consecutive superficial and mid dermal partial thickness burn injuries were prospectively treated with Biobrane™ within 12h of the injury. This 'early Biobrane™' cohort was compared to a historical cohort of 148 patients who were treated with Biobrane™ for superficial and mid dermal burns after 12h after injury during 2015 to 2016. Multivariate regression analysis was used to determine the difference in time to re-epithelialisation and number of outpatient visits between the two cohorts.
In the 'early Biobrane™' group, the mean TBSA was 3.5±2.7%. and the mean time to Biobrane™ application was 7.1±2.7h after burn injury. The mean time to re-epithelialisation in this group was 9.1±3.0 days, and no patients underwent skin grafting. In the 'delayed Biobrane™' group, the mean TBSA was 2.6±2.8% and the mean time to Biobrane™ application was 35.1±21.4h. The mean time to re-epithelialisation was 14.8±8.7 days, with 3 patients undergoing skin grafting. Regression analysis demonstrated a statistically significant 63% reduction in time to re-epithelialisation (95% CI=0.23-0.60; P<0.0001) with early Biobrane™ application.
Patients treated with application of Biobrane™ within 12h of superficial and mid dermal partial thickness burns have a statistically significant reduction in healing time when compared to patients treated with standard Biobrane™ practice.
Biobrane™ 是一种用于治疗部分厚度烧伤的皮肤替代物。尚无研究检查在这种情况下将 Biobrane™ 应用于浅表和中真皮部分厚度烧伤的最佳时机。本研究的目的是确定在烧伤后 12 小时内将 Biobrane™ 应用于浅表和中真皮部分厚度烧伤是否在临床上有显著差异。
2016 年 8 月至 2017 年 2 月，连续 29 例浅表和中真皮部分厚度烧伤患者在受伤后 12 小时内用 Biobrane™ 进行前瞻性治疗。该“早期 Biobrane™”队列与 2015 年至 2016 年期间接受 Biobrane™ 治疗的 148 例浅表和中真皮烧伤患者的历史队列进行比较。多元回归分析用于确定两个队列之间再上皮化时间和门诊就诊次数的差异。
在“早期 Biobrane™”组中，平均 TBSA 为 3.5±2.7%，Biobrane™ 应用于烧伤后的平均时间为 7.1±2.7 小时。该组的平均再上皮化时间为 9.1±3.0 天，没有患者接受皮肤移植。在“延迟 Biobrane™”组中，平均 TBSA 为 2.6±2.8%，Biobrane™ 应用于烧伤后的平均时间为 35.1±21.4 小时。平均再上皮化时间为 14.8±8.7 天，有 3 例患者接受皮肤移植。回归分析表明，早期应用 Biobrane™ 可使再上皮化时间显著缩短 63%（95%CI=0.23-0.60；P<0.0001）。
与接受标准 Biobrane™ 治疗的患者相比，在浅表和中真皮部分厚度烧伤后 12 小时内应用 Biobrane™ 的患者愈合时间有统计学显著缩短。
