Department of Child and Adolescent Psychiatry and Psychology, Institute of Neurosciences, Hospital Clinic de Barcelona, C/ Villarroel 170, E-08036 Barcelona, Spain.
Department of Clinical Foundations, Pharmacology Unit, University of Barcelona, Barcelona, Spain.
Psychiatry Res. 2019 Jan;271:554-558. doi: 10.1016/j.psychres.2018.12.019. Epub 2018 Dec 6.
The age of onset of some psychiatric disorders may have etiopathogenic and clinical effects and may influence outcome. Following on from previous work by our group where we showed that early onset anorexia nervosa (AN) and obsessive-compulsive disorder (OCD) shared a common genetic background, the aim of the present study is to assess genetic pleiotropy related to the serotonergic system (SLC6A4, 5HTR2A, 5HTR2C, TPH2, SLC18A1), in a common phenotype such as very-early age of onset. One hundred and sixteen adolescents diagnosed with AN and 74 adolescents diagnosed with OCD participated in the present study. We confirmed the existence of a genetic overlap between OCD and AN. Specifically, we described genetic pleiotropy for age at onset across these disorders, associating two SNPs (rs6311, rs4942587) of the HTR2A with the very-early onset phenotype.
一些精神疾病的发病年龄可能具有病因和临床影响，并可能影响结果。继我们之前的研究表明，早发性厌食症（AN）和强迫症（OCD）具有共同的遗传背景之后，本研究的目的是评估与血清素能系统（SLC6A4、5HTR2A、5HTR2C、TPH2、SLC18A1）相关的遗传多效性，在早发性等常见表型中。116 名被诊断为 AN 的青少年和 74 名被诊断为 OCD 的青少年参加了本研究。我们证实了 OCD 和 AN 之间存在遗传重叠。具体来说，我们描述了这些疾病发病年龄的遗传多效性，将 HTR2A 的两个 SNP（rs6311，rs4942587）与非常早发性表型相关联。
