FOXP2 常见遗传变异与精神分裂症语言障碍之间没有关联。
No association between common genetic variation in FOXP2 and language impairment in schizophrenia.
机构信息
Division of Psychiatry, Centre for Clinical Research in Neuropsychiatry, Faculty of Health and Medical Sciences, The University of Western Australia, Medical Research Foundation Building, Perth WA 6000, Australia; Centre for the Genetic Origins of Health and Disease, Faculty of Health Sciences, Curtin University and Faculty of Health and Medical Sciences, The University of Western Australia, Medical Research Foundation Building, Perth WA 6000, Australia.
Division of Psychiatry, Centre for Clinical Research in Neuropsychiatry, Faculty of Health and Medical Sciences, The University of Western Australia, Medical Research Foundation Building, Perth WA 6000, Australia.
出版信息
Psychiatry Res. 2019 Jan;271:590-597. doi: 10.1016/j.psychres.2018.12.016. Epub 2018 Dec 6.
The FOXP2 gene is hypothesised to be involved in schizophrenia by affecting speech and language development. Associations between common single nucleotide polymorphisms (SNPs) in FOXP2 and language have been inconsistent. We tested five previously associated SNPs for association with language in the Western Australian Family Study of Schizophrenia (n = 709, including n = 333 with schizophrenia/spectrum disorder) and found no significant associations. When we included all common FOXP2 variants, one SNP (rs2189008) was nominally associated with language. This is the most comprehensive analysis to date and indicates that common variants in FOXP2 do not play a major role in speech and language development in a clinical family sample.
FOXP2 基因被假设通过影响言语和语言发展而与精神分裂症有关。FOXP2 中常见的单核苷酸多态性 (SNP) 与语言之间的关联并不一致。我们在西澳大利亚精神分裂症家系研究 (n=709，包括 n=333 例精神分裂症/谱系障碍) 中测试了五个先前与语言相关的 SNP 是否与语言有关，并未发现显著关联。当我们纳入所有常见的 FOXP2 变体时，一个 SNP(rs2189008) 与语言呈名义相关。这是迄今为止最全面的分析，表明 FOXP2 中的常见变体在临床家族样本的言语和语言发展中不起主要作用。
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