Prague Psychiatric Centre, Prague, Czech Republic.
Neurosci Lett. 2011 Apr 15;493(3):131-5. doi: 10.1016/j.neulet.2011.02.024. Epub 2011 Feb 18.
FOXP2, the first gene known to be involved in the development of speech and language, can be considered to be, a priori, a candidate gene in schizophrenia, given the mounting evidence that the underlying core deficit in this disease could be a failure of structures relevant to normal language processing. To investigate the potential link between grey matter concentration (GMC) changes in patients with schizophrenia and the FOXP2 rs2396753 polymorphism previously reported to be associated with hallucinations in schizophrenia, we analysed high-resolution anatomical magnetic resonance images of 40 genotyped patients with schizophrenia and 36 healthy controls, using optimised voxel-based morphometry (VBM). Here we show that the common SNP rs2396753 (C>A) gene variant of the FOXP2 gene has significant effects on GMC in patients with schizophrenia, within regions of the brain known to be affected by this disease. Our data suggest that GMC reductions in schizophrenia may be driven by C allele carriers of the FOXP2 gene variant.
FOXP2 是已知第一个与言语和语言发展相关的基因，可以被认为是精神分裂症的候选基因，因为越来越多的证据表明，这种疾病的核心缺陷可能是与正常语言处理相关的结构出现故障。为了研究精神分裂症患者的灰质浓度 (GMC) 变化与先前报道与精神分裂症幻觉相关的 FOXP2 rs2396753 多态性之间的潜在联系，我们使用优化的基于体素的形态测量学 (VBM) 分析了 40 名基因分型的精神分裂症患者和 36 名健康对照者的高分辨率解剖磁共振图像。在这里，我们表明 FOXP2 基因的常见 SNP rs2396753 (C>A) 基因变异对精神分裂症患者的 GMC 有显著影响，在已知受该疾病影响的大脑区域内。我们的数据表明，FOXP2 基因变异的 C 等位基因携带者可能导致精神分裂症中的 GMC 减少。
