Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran; Biotechnology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran; Department of Pharmaceutical Biotechnology, Faculty of Pharmacy, Tabriz University of Medical Sciences, Tabriz, Iran.
Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Tabriz University of Medical Sciences, Tabriz, Iran; Student Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran.
Biomed Pharmacother. 2019 Feb;110:775-785. doi: 10.1016/j.biopha.2018.12.022. Epub 2018 Dec 13.
Angiogenesis is a critical step in the progression of almost all human malignancies and some other life-threatening diseases. Anti-angiogenic therapy is a novel and effective approach for treatment of angiogenesis-dependent diseases such as cancer, diabetic retinopathy, and age-related macular degeneration. In this article, we will review the main strategies developed for anti-angiogenic therapies beside their clinical applications, the major challenges, and the latest advances in the development of anti-angiogenesis-based targeted therapies.
血管生成是几乎所有人类恶性肿瘤和一些其他危及生命的疾病进展的关键步骤。抗血管生成治疗是治疗依赖血管生成的疾病（如癌症、糖尿病性视网膜病变和年龄相关性黄斑变性）的一种新颖而有效的方法。在本文中，我们将回顾除了临床应用之外，为抗血管生成治疗开发的主要策略、主要挑战以及基于抗血管生成的靶向治疗的最新进展。
