Gong Husile, Yang Ding, Qi Yunxia, Wu Jianghong, Zhang Wenguang
College of Life Science, Inner Mongolia University for Nationalities, Tongliao, 028000, China.
College of Animal Science, Inner Mongolia Agricultural University, Hohhot, 010018, China.
Biochem Genet. 2019 Jun;57(3):371-381. doi: 10.1007/s10528-018-9897-y. Epub 2018 Dec 15.
The skin is the primary barrier between the internal organs of an organism and the environment, and it provides protection from ultraviolet (UV) radiation. According to the nocturnal bottleneck hypothesis, ungulates might have traversed to the grasslands and were exposed to UV radiation subsequent to the reduction in predation pressure. UV light exposure might have increased the S100A7 expression. In order to test whether the UV radiation is associated with the selection pressure on S100A7, we acquired the complete S100A7 DNA sequences from each of 42 vertebrate species. The results suggested that the evidence of diversifying selection in S100A7 occurred at the end of Mesozoic era, and the site of positive selection was observed in the branch of Artiodactyla (even-toed ungulates). In addition, we found that the transcription level of S100A7 in cashmere goat skin correlates with UV radiation. Our results indicated that S100A7 plays a role in the signaling between the skin genes and UV radiation during evolution.
皮肤是生物体内部器官与外界环境之间的主要屏障，它能保护机体免受紫外线（UV）辐射。根据夜间瓶颈假说，有蹄类动物可能在捕食压力降低后转移到草原并暴露于紫外线辐射之下。紫外线照射可能增加了S100A7的表达。为了测试紫外线辐射是否与S100A7上的选择压力相关，我们从42种脊椎动物物种中分别获取了完整的S100A7 DNA序列。结果表明，S100A7中多样化选择的证据出现在中生代末期，并且在偶蹄目（偶蹄有蹄类动物）分支中观察到了正选择位点。此外，我们发现绒山羊皮肤中S100A7的转录水平与紫外线辐射相关。我们的结果表明，S100A7在进化过程中皮肤基因与紫外线辐射之间的信号传导中发挥作用。
